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1iip

From Proteopedia

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{{Seed}}
 
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[[Image:1iip.png|left|200px]]
 
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<!--
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==Bovine Cyclophilin 40, Tetragonal Form==
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The line below this paragraph, containing "STRUCTURE_1iip", creates the "Structure Box" on the page.
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<StructureSection load='1iip' size='340' side='right'caption='[[1iip]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1iip]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IIP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_1iip| PDB=1iip | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iip OCA], [https://pdbe.org/1iip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iip RCSB], [https://www.ebi.ac.uk/pdbsum/1iip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iip ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPID_BOVIN PPID_BOVIN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis.<ref>PMID:1544925</ref> <ref>PMID:16650407</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/1iip_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iip ConSurf].
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<div style="clear:both"></div>
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===Bovine Cyclophilin 40, Tetragonal Form===
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==See Also==
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*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11377203}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11377203 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_11377203}}
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==About this Structure==
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1IIP is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIP OCA].
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==Reference==
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<ref group="xtra">PMID:11377203</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Carrello, A.]]
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[[Category: Carrello A]]
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[[Category: Dornan, J.]]
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[[Category: Dornan J]]
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[[Category: Minchin, R F.]]
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[[Category: Minchin RF]]
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[[Category: Ratajczak, T.]]
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[[Category: Ratajczak T]]
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[[Category: Taylor, P.]]
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[[Category: Taylor P]]
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[[Category: Walkinshaw, M D.]]
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[[Category: Walkinshaw MD]]
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[[Category: Ppiase immunophilin tetratricopeptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:03:03 2009''
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Current revision

Bovine Cyclophilin 40, Tetragonal Form

PDB ID 1iip

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