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1ijs

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{{Seed}}
 
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[[Image:1ijs.png|left|200px]]
 
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==CPV (STRAIN D) mutant A300D, complex (VIRAL COAT/DNA), VP2, PH=7.5, T=4 DEGREES C==
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The line below this paragraph, containing "STRUCTURE_1ijs", creates the "Structure Box" on the page.
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<StructureSection load='1ijs' size='340' side='right'caption='[[1ijs]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ijs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Canine_parvovirus Canine parvovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IJS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ijs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ijs OCA], [https://pdbe.org/1ijs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ijs RCSB], [https://www.ebi.ac.uk/pdbsum/1ijs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ijs ProSAT]</span></td></tr>
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{{STRUCTURE_1ijs| PDB=1ijs | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSD_PAVCD CAPSD_PAVCD] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptor TFRC. This attachment induces virion internalization predominantly through clathrin-endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell (By similarity). Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein. Exposure of nuclear localization signal probably allows nuclear import of capsids.<ref>PMID:11799183</ref> <ref>PMID:12970411</ref> <ref>PMID:19656887</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ij/1ijs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ijs ConSurf].
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<div style="clear:both"></div>
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===CPV(STRAIN D) MUTANT A300D, COMPLEX(VIRAL COAT/DNA), VP2, PH=7.5, T=4 DEGREES C===
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==See Also==
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*[[Canine parvovirus|Canine parvovirus]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_8918534}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 8918534 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_8918534}}
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==About this Structure==
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1IJS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Canine_parvovirus Canine parvovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJS OCA].
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==Reference==
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Structural analysis of a mutation in canine parvovirus which controls antigenicity and host range., Llamas-Saiz AL, Agbandje-McKenna M, Parker JS, Wahid AT, Parrish CR, Rossmann MG, Virology. 1996 Nov 1;225(1):65-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8918534 8918534]
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[[Category: Canine parvovirus]]
[[Category: Canine parvovirus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Agbandje-McKenna, M.]]
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[[Category: Agbandje-McKenna M]]
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[[Category: Llamas-Saiz, A L.]]
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[[Category: Llamas-Saiz AL]]
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[[Category: Parker, J S.L.]]
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[[Category: Parker JSL]]
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[[Category: Parrish, C R.]]
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[[Category: Parrish CR]]
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[[Category: Rossmann, M. G.]]
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[[Category: Rossmann MG]]
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[[Category: Wahid, A T.M.]]
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[[Category: Wahid ATM]]
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[[Category: Icosahedral virus]]
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[[Category: Mutant a300d]]
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[[Category: Viral coat protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:23:47 2008''
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Current revision

CPV (STRAIN D) mutant A300D, complex (VIRAL COAT/DNA), VP2, PH=7.5, T=4 DEGREES C

PDB ID 1ijs

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