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1is6

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[[Image:1is6.jpg|left|200px]]
 
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{{Structure
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==MES-Liganded Congerin II==
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|PDB= 1is6 |SIZE=350|CAPTION= <scene name='initialview01'>1is6</scene>, resolution 1.7&Aring;
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<StructureSection load='1is6' size='340' side='right'caption='[[1is6]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC ACID'>MES</scene>
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<table><tr><td colspan='2'>[[1is6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IS6 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1is6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1is6 OCA], [https://pdbe.org/1is6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1is6 RCSB], [https://www.ebi.ac.uk/pdbsum/1is6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1is6 ProSAT]</span></td></tr>
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</table>
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'''MES-Liganded Congerin II'''
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== Function ==
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[https://www.uniprot.org/uniprot/LEG2_CONMY LEG2_CONMY] This protein binds beta-galactoside. Its physiological function is not yet known.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The crystal structure of congerin II, a galectin family lectin from conger eel, was determined at 1.45A resolution. The previously determined structure of its isoform, congerin I, had revealed a fold evolution via strand swap; however, the structure of congerin II described here resembles other prototype galectins. A comparison of the two congerin genes with that of several other galectins suggests acceralated evolution of both congerin genes following gene duplication. The presence of a Mes (2-[N-morpholino]ethanesulfonic acid) molecule near the carbohydrate-binding site in the crystal structure points to the possibility of an additional binding site in congerin II. The binding site consists of a group of residues that had been replaced following gene duplication suggesting that the binding site was built under selective pressure. Congerin II may be a protein specialized for biological defense with an affinity for target carbohydrates on parasites' cell surface.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/1is6_consurf.spt"</scriptWhenChecked>
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1IS6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IS6 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of a conger eel galectin (congerin II) at 1.45A resolution: implication for the accelerated evolution of a new ligand-binding site following gene duplication., Shirai T, Matsui Y, Shionyu-Mitsuyama C, Yamane T, Kamiya H, Ishii C, Ogawa T, Muramoto K, J Mol Biol. 2002 Aug 30;321(5):879-89. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12206768 12206768]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1is6 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Conger myriaster]]
[[Category: Conger myriaster]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ishii, C.]]
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[[Category: Ishii C]]
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[[Category: Kamiya, H.]]
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[[Category: Kamiya H]]
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[[Category: Matsui, Y.]]
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[[Category: Matsui Y]]
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[[Category: Muramoto, K.]]
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[[Category: Muramoto K]]
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[[Category: Ogawa, T.]]
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[[Category: Ogawa T]]
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[[Category: Shionyu-Mitsuyama, C.]]
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[[Category: Shionyu-Mitsuyama C]]
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[[Category: Shirai, T.]]
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[[Category: Shirai T]]
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[[Category: Yamane, T.]]
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[[Category: Yamane T]]
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[[Category: MES]]
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[[Category: beta sandwich]]
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[[Category: mes complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:54:13 2008''
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Current revision

MES-Liganded Congerin II

PDB ID 1is6

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