This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1jck

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1jck" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jck, resolution 3.5&Aring;" /> '''T-CELL RECEPTOR BETA ...)
Current revision (06:03, 3 April 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1jck.gif|left|200px]]<br /><applet load="1jck" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1jck, resolution 3.5&Aring;" />
 
-
'''T-CELL RECEPTOR BETA CHAIN COMPLEXED WITH SEC3 SUPERANTIGEN'''<br />
 
-
==Overview==
+
==T-CELL RECEPTOR BETA CHAIN COMPLEXED WITH SEC3 SUPERANTIGEN==
-
Superantigens (SAgs) are viral or bacterial proteins that act as potent, T-cell stimulants and have been implicated in a number of human diseases, including toxic shock syndrome, diabetes mellitus and multiple sclerosis., The interaction of SAgs with the T-cell receptor (TCR) and major, histocompatibility complex (MHC) proteins results in the stimulation of a, disproportionately large fraction of the T-cell population. We report here, the crystal structures of the beta-chain of a TCR complexed with the, Staphylococcus aureus enterotoxins C2 and C3 (SEC2, SEC3). These, enterotoxins, which cause both toxic shock and food poisoning, bind in an, identical way to the TCR beta-chain. The complementarity-determining, region 2 (CDR2) of the beta-chain and, to lesser extents, CDR1 and, hypervariable region 4 (HV4), bind in a cleft between the two domains of, the SAgs. Thus, there is considerable overlap between the SAg-binding site, and the peptide/MHC-binding sites of the TCR. A model of a TCR-SAg-MHC, complex constructed from the crystal structures of (1) the beta-chain-SEC3, complex, (2) a complex between staphylococcal enterotoxin B (SEB) and an, MHC molecule, and (3) a TCR V(alpha) domain, reveals that the SAg acts as, a wedge between the TCR and MHC to displace the antigenic peptide away, from the TCR combining site. In this way, the SAg is able to circumvent, the normal mechanism for T-cell activation by specific peptide/MHC, complexes.
+
<StructureSection load='1jck' size='340' side='right'caption='[[1jck]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1jck]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JCK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JCK FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jck OCA], [https://pdbe.org/1jck PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jck RCSB], [https://www.ebi.ac.uk/pdbsum/1jck PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jck ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ENTC3_STAAU ENTC3_STAAU] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/1jck_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jck ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1JCK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JCK OCA].
+
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
Crystal structure of a T-cell receptor beta-chain complexed with a superantigen., Fields BA, Malchiodi EL, Li H, Ysern X, Stauffacher CV, Schlievert PM, Karjalainen K, Mariuzza RA, Nature. 1996 Nov 14;384(6605):188-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8906797 8906797]
+
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Protein complex]]
 
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
-
[[Category: Fields, B.A.]]
+
[[Category: Fields BA]]
-
[[Category: Mariuzza, R.A.]]
+
[[Category: Mariuzza RA]]
-
[[Category: complex (toxin/receptor)]]
+
-
[[Category: enterotoxin]]
+
-
[[Category: glycoprotein]]
+
-
[[Category: receptor]]
+
-
[[Category: signal]]
+
-
[[Category: superantigen]]
+
-
[[Category: t-cell]]
+
-
[[Category: toxin]]
+
-
[[Category: transmembrane]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:06:36 2007''
+

Current revision

T-CELL RECEPTOR BETA CHAIN COMPLEXED WITH SEC3 SUPERANTIGEN

PDB ID 1jck

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jck"
Personal tools