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1jmy

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{{Seed}}
 
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[[Image:1jmy.png|left|200px]]
 
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<!--
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==Truncated Recombinant Human Bile Salt Stimulated Lipase==
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The line below this paragraph, containing "STRUCTURE_1jmy", creates the "Structure Box" on the page.
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<StructureSection load='1jmy' size='340' side='right'caption='[[1jmy]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jmy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JMY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1jmy| PDB=1jmy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jmy OCA], [https://pdbe.org/1jmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jmy RCSB], [https://www.ebi.ac.uk/pdbsum/1jmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jmy ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CEL_HUMAN CEL_HUMAN] Defects in CEL are a cause of maturity-onset diabetes of the young type 8 with exocrine dysfunction (MODY8) [MIM:[https://omim.org/entry/609812 609812]; also known as diabetes and pancreatic exocrine dysfunction (DPED). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:16369531</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CEL_HUMAN CEL_HUMAN] Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/1jmy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jmy ConSurf].
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<div style="clear:both"></div>
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===Truncated Recombinant Human Bile Salt Stimulated Lipase===
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==See Also==
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*[[Cholesterol esterase 3D structures|Cholesterol esterase 3D structures]]
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*[[Lipase 3D Structures|Lipase 3D Structures]]
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<!--
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_11563913}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 11563913 is the PubMed ID number.
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__TOC__
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-->
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</StructureSection>
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{{ABSTRACT_PUBMED_11563913}}
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==About this Structure==
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1JMY is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMY OCA].
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==Reference==
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<ref group="xtra">PMID:11563913</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Triacylglycerol lipase]]
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[[Category: Large Structures]]
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[[Category: Baker, E N.]]
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[[Category: Baker EN]]
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[[Category: Baker, H M.]]
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[[Category: Baker HM]]
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[[Category: Blackberg, L.]]
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[[Category: Blackberg L]]
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[[Category: Hernell, O.]]
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[[Category: Hernell O]]
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[[Category: Kingston, R L.]]
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[[Category: Kingston RL]]
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[[Category: Loomes, K M.]]
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[[Category: Loomes KM]]
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[[Category: Moore, S A.]]
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[[Category: Moore SA]]
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[[Category: Bile salt dependent lipase]]
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[[Category: Bile salt stimulated lipase]]
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[[Category: Bsdl]]
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[[Category: Bssl]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:56:32 2009''
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Current revision

Truncated Recombinant Human Bile Salt Stimulated Lipase

PDB ID 1jmy

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