This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1jnu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:04, 3 April 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1jnu.gif|left|200px]]
 
-
{{Structure
+
==Photoexcited structure of the plant photoreceptor domain, phy3 LOV2==
-
|PDB= 1jnu |SIZE=350|CAPTION= <scene name='initialview01'>1jnu</scene>, resolution 2.60&Aring;
+
<StructureSection load='1jnu' size='340' side='right'caption='[[1jnu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>
+
<table><tr><td colspan='2'>[[1jnu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Adiantum_capillus-veneris Adiantum capillus-veneris]. The March 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JNU FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
|GENE= phy3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2759 Eukaryota])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnu OCA], [https://pdbe.org/1jnu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jnu RCSB], [https://www.ebi.ac.uk/pdbsum/1jnu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jnu ProSAT]</span></td></tr>
-
|RELATEDENTRY=[[1g28|1G28]], [[2phy|2PHY]], [[1drm|1DRM]], [[1byw|1BYW]]
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnu OCA], [http://www.ebi.ac.uk/pdbsum/1jnu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jnu RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/Q9ZWQ6_ADICA Q9ZWQ6_ADICA]
-
 
+
== Evolutionary Conservation ==
-
'''Photoexcited structure of the plant photoreceptor domain, phy3 LOV2'''
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==Overview==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jnu_consurf.spt"</scriptWhenChecked>
-
The phototropins are flavoprotein kinases that control phototropic bending, light-induced chloroplast movement, and stomatal opening in plants. Two flavin mononucleotide binding light, oxygen, or voltage (LOV) domains are the sites for initial photochemistry in these blue light photoreceptors. We have determined the steady state, photoexcited crystal structure of a flavin-bound LOV domain. The structure reveals a unique photochemical switch in the flavin binding pocket in which the absorption of light drives the formation of a reversible covalent bond between a highly conserved Cys residue and the flavin cofactor. This provides a molecular picture of a cysteinyl-flavin covalent adduct, the presumed signaling species that leads to phototropin kinase activation and subsequent signal transduction. We identify closely related LOV domains in two eubacterial proteins that suggests the light-induced conformational change evident in this structure is an ancient biomolecular response to light, arising before the appearance of plants.
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1JNU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Eukaryota Eukaryota]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNU OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jnu ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
__TOC__
-
Photoexcited structure of a plant photoreceptor domain reveals a light-driven molecular switch., Crosson S, Moffat K, Plant Cell. 2002 May;14(5):1067-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12034897 12034897]
+
</StructureSection>
-
[[Category: Eukaryota]]
+
[[Category: Adiantum capillus-veneris]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Crosson, S.]]
+
[[Category: Phototropin]]
-
[[Category: Moffat, K.]]
+
[[Category: RCSB PDB Molecule of the Month]]
-
[[Category: cysteinyl-flavin adduct]]
+
[[Category: Crosson S]]
-
[[Category: light-driven bond]]
+
[[Category: Moffat K]]
-
[[Category: lov]]
+
-
[[Category: pa]]
+
-
[[Category: photochemistry]]
+
-
[[Category: photoexcited]]
+
-
[[Category: phototropin]]
+
-
[[Category: phy3]]
+
-
[[Category: plant photoreceptor]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:36:18 2008''
+

Current revision

Photoexcited structure of the plant photoreceptor domain, phy3 LOV2

PDB ID 1jnu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jnu"
Personal tools