1lpy

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{{Seed}}
 
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[[Image:1lpy.png|left|200px]]
 
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==Multiple Methionine Substitutions in T4 Lysozyme==
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The line below this paragraph, containing "STRUCTURE_1lpy", creates the "Structure Box" on the page.
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<StructureSection load='1lpy' size='340' side='right'caption='[[1lpy]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lpy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LPY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1lpy| PDB=1lpy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lpy OCA], [https://pdbe.org/1lpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lpy RCSB], [https://www.ebi.ac.uk/pdbsum/1lpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lpy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lp/1lpy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lpy ConSurf].
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<div style="clear:both"></div>
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===Multiple Methionine Substitutions in T4 Lysozyme===
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==See Also==
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12646375}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12646375 is the PubMed ID number.
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</StructureSection>
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[[Category: Escherichia virus T4]]
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{{ABSTRACT_PUBMED_12646375}}
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[[Category: Large Structures]]
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[[Category: Baase WA]]
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==About this Structure==
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[[Category: Busam RD]]
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1LPY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPY OCA].
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[[Category: Gassner NC]]
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[[Category: Lindstrom JD]]
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==Reference==
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[[Category: Matthews BW]]
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Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability., Gassner NC, Baase WA, Mooers BH, Busam RD, Weaver LH, Lindstrom JD, Quillin ML, Matthews BW, Biophys Chem. 2003;100(1-3):325-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12646375 12646375]
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[[Category: Mooers BHM]]
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[[Category: Enterobacteria phage t4]]
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[[Category: Quillin ML]]
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[[Category: Lysozyme]]
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[[Category: Weaver LH]]
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[[Category: Single protein]]
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[[Category: Baase, W A.]]
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[[Category: Busam, R D.]]
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[[Category: Gassner, N C.]]
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[[Category: Lindstrom, J D.]]
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[[Category: Matthews, B W.]]
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[[Category: Mooers, B H.M.]]
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[[Category: Quillin, M L.]]
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[[Category: Weaver, L H.]]
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[[Category: Methionine core mutant]]
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[[Category: Protein engineering]]
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[[Category: Protein folding]]
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[[Category: T4 lysozyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:45:55 2008''
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Current revision

Multiple Methionine Substitutions in T4 Lysozyme

PDB ID 1lpy

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