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1lyc

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(New page: 200px<br /><applet load="1lyc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lyc, resolution 1.57&Aring;" /> '''The impact of the ph...)
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[[Image:1lyc.jpg|left|200px]]<br /><applet load="1lyc" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1lyc, resolution 1.57&Aring;" />
 
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'''The impact of the physical and chemical enviroment on the molecular structure of Coprinus cinereus peroxidase'''<br />
 
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==Overview==
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==The impact of the physical and chemical enviroment on the molecular structure of Coprinus cinereus peroxidase==
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The structure of the peroxidase from Coprinus cinereus (CiP) has been, determined in three different space groups and crystalline environments., Two of these are of the recombinant glycosylated form (rCiP), which, crystallized in space groups P2(1)2(1)2(1) and C2. The third crystal form, was obtained from a variant of CiP in which the glycosylation sites have, been removed (rCiPON). It crystallizes in space group P2(1) with beta, approximately 90 degrees; the structure was determined from, room-temperature data and low-temperature data obtained from twinned, crystals. Two independent molecules of CiP related by non-crystallographic, symmetry are contained in the three crystal forms. The packing in the two, structures of the glycosylated form of rCiP is closely related, but, differs from the packing in the unglycosylated rCiPON. A database search, based on small-molecule porphinato iron (III) complexes has been performed, and related to observations of the spin states and coordination numbers of, the iron ion. The room-temperature structures of CiP and one structure of, the almost identical peroxidase from Arthromyces ramosus (ARP) have been, used to identify 66 conserved water molecules and to assign a structural, role to most of them.
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<StructureSection load='1lyc' size='340' side='right'caption='[[1lyc]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1lyc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LYC FirstGlance]. <br>
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1LYC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea] with CA and HEM as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LYC OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lyc OCA], [https://pdbe.org/1lyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lyc RCSB], [https://www.ebi.ac.uk/pdbsum/1lyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lyc ProSAT]</span></td></tr>
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Impact of the physical and chemical environment on the molecular structure of Coprinus cinereus peroxidase., Houborg K, Harris P, Petersen J, Rowland P, Poulsen JC, Schneider P, Vind J, Larsen S, Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):989-96. Epub 2003, May 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12777760 12777760]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PER_COPCI PER_COPCI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ly/1lyc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lyc ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Coprinopsis cinerea]]
[[Category: Coprinopsis cinerea]]
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[[Category: Peroxidase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Harris P]]
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[[Category: Harris, P.]]
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[[Category: Houborg K]]
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[[Category: Houborg, K.]]
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[[Category: Larsen S]]
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[[Category: Larsen, S.]]
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[[Category: Petersen JFW]]
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[[Category: Petersen, J.F.W.]]
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[[Category: Poulsen J-CN]]
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[[Category: Poulsen, J.C.N.]]
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[[Category: Rowland P]]
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[[Category: Rowland, P.]]
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[[Category: Schneider P]]
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[[Category: Schneider, P.]]
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[[Category: Vind J]]
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[[Category: Vind, J.]]
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[[Category: CA]]
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[[Category: HEM]]
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[[Category: coprinus cinereus]]
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[[Category: mutant]]
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[[Category: peroxidase]]
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[[Category: thermostability]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 20:58:48 2007''
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Current revision

The impact of the physical and chemical enviroment on the molecular structure of Coprinus cinereus peroxidase

PDB ID 1lyc

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