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1m24

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(New page: 200px<br /><applet load="1m24" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m24, resolution 0.90&Aring;" /> '''Trichotoxin_A50E, An...)
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[[Image:1m24.jpg|left|200px]]<br /><applet load="1m24" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1m24, resolution 0.90&Aring;" />
 
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'''Trichotoxin_A50E, An Ion Channel-Forming Polypeptide'''<br />
 
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==Overview==
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==Trichotoxin_A50E, An Ion Channel-Forming Polypeptide==
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Trichotoxin_A50E is an 18-residue peptaibol antibiotic which forms, multimeric transmembrane channels through self-association. The crystal, structure of trichotoxin has been determined at a resolution of 0.9 A. The, trichotoxin sequence contains nine helix-promoting Aib residues, which, contribute to the formation of an entirely helical structure that has a, central bend of 8-10 degrees located between residues 10-13. Trichotoxin, is the first solved structure of the peptaibol family that is all, alpha-helix as opposed to containing part or all 3(10)-helix. Gln residues, in positions 6 and 17 produce a polar face, and are proposed to form the, channel lumen. An octameric model channel has been constructed from the, crystal structure. It has a central pore of approximately 4-5 A radius, a, size sufficient to enable transport of ions, with a constricted region at, one end, formed by a ring of Gln6 residues. Electrostatic calculations are, consistent with it being a cationic channel.
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<StructureSection load='1m24' size='340' side='right'caption='[[1m24]], [[Resolution|resolution]] 0.90&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1m24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoderma_viride Trichoderma viride]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M24 FirstGlance]. <br>
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1M24 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Trichoderma_viride Trichoderma viride] with ACE and CCN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1M24 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=PRD_000160:TRICHOTOXIN+A50E'>PRD_000160</scene>, <scene name='pdbligand=VOL:L-VALINOL'>VOL</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m24 OCA], [https://pdbe.org/1m24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m24 RCSB], [https://www.ebi.ac.uk/pdbsum/1m24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m24 ProSAT]</span></td></tr>
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Model for a helical bundle channel based on the high-resolution crystal structure of trichotoxin_A50E., Chugh JK, Bruckner H, Wallace BA, Biochemistry. 2002 Oct 29;41(43):12934-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12390019 12390019]
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</table>
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[[Category: Protein complex]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Trichoderma viride]]
[[Category: Trichoderma viride]]
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[[Category: Brueckner, H.]]
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[[Category: Brueckner H]]
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[[Category: Chugh, J.K.]]
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[[Category: Chugh JK]]
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[[Category: Wallace, B.A.]]
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[[Category: Wallace BA]]
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[[Category: ACE]]
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[[Category: CCN]]
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[[Category: antibiotic]]
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[[Category: helical bundle]]
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[[Category: ion channel]]
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[[Category: peptaibol]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:40:50 2007''
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Current revision

Trichotoxin_A50E, An Ion Channel-Forming Polypeptide

PDB ID 1m24

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