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1m2t

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[[Image:1m2t.png|left|200px]]
 
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{{STRUCTURE_1m2t| PDB=1m2t | SCENE= }}
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==Mistletoe Lectin I from Viscum album in Complex with Adenine Monophosphate. Crystal Structure at 1.9 A Resolution==
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<StructureSection load='1m2t' size='340' side='right'caption='[[1m2t]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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===Mistletoe Lectin I from Viscum album in Complex with Adenine Monophosphate. Crystal Structure at 1.9 A Resolution===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1m2t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M2T FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12351890}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2t OCA], [https://pdbe.org/1m2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m2t RCSB], [https://www.ebi.ac.uk/pdbsum/1m2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m2t ProSAT]</span></td></tr>
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[[1m2t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2T OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>
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<ref group="xtra">PMID:012351890</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m2/1m2t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m2t ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Viscum album]]
[[Category: Viscum album]]
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[[Category: RRNA N-glycosylase]]
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[[Category: Betzel C]]
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[[Category: Betzel, C.]]
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[[Category: DeLucas L]]
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[[Category: DeLucas, L.]]
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[[Category: Kalkura N]]
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[[Category: Kalkura, N.]]
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[[Category: Krauspenhaar R]]
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[[Category: Krauspenhaar, R.]]
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[[Category: Mikhailov A]]
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[[Category: Mikhailov, A.]]
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[[Category: Moore K]]
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[[Category: Moore, K.]]
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[[Category: Rypniewski W]]
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[[Category: Rypniewski, W.]]
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[[Category: Stoeva S]]
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[[Category: Stoeva, S.]]
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[[Category: Voelter W]]
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[[Category: Voelter, W.]]
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[[Category: Hydrolase]]
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[[Category: Ribosome inactivation]]
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[[Category: Ribosome inhibitor]]
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Current revision

Mistletoe Lectin I from Viscum album in Complex with Adenine Monophosphate. Crystal Structure at 1.9 A Resolution

PDB ID 1m2t

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