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1n26

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[[Image:1n26.png|left|200px]]
 
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{{STRUCTURE_1n26| PDB=1n26 | SCENE= }}
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==Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain==
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<StructureSection load='1n26' size='340' side='right'caption='[[1n26]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1n26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N26 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12461182}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n26 OCA], [https://pdbe.org/1n26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n26 RCSB], [https://www.ebi.ac.uk/pdbsum/1n26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n26 ProSAT]</span></td></tr>
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[[1n26]] is a 1 chain structure of [[Interleukin receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N26 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL6RA_HUMAN IL6RA_HUMAN] Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref> Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n2/1n26_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n26 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Interleukin receptor|Interleukin receptor]]
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*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012461182</ref><ref group="xtra">PMID:015895091</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Branson, K M.]]
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[[Category: Large Structures]]
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[[Category: Donkelaar, A van.]]
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[[Category: Branson KM]]
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[[Category: Hall, N E.]]
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[[Category: Hall NE]]
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[[Category: Ivancic, N.]]
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[[Category: Ivancic N]]
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[[Category: Ji, H.]]
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[[Category: Ji H]]
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[[Category: Lou, M Z.]]
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[[Category: Lou M-Z]]
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[[Category: Moritz, R L.]]
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[[Category: Moritz RL]]
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[[Category: Simpson, R J.]]
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[[Category: Simpson RJ]]
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[[Category: Varghese, J N.]]
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[[Category: Varghese JN]]
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[[Category: Cytokine]]
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[[Category: Van Donkelaar A]]
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[[Category: Glycoprotein]]
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[[Category: Immunoglobulin domain]]
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[[Category: Transmembrane]]
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Current revision

Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain

PDB ID 1n26

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