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1n8o

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==Crystal structure of a complex between bovine chymotrypsin and ecotin==
==Crystal structure of a complex between bovine chymotrypsin and ecotin==
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<StructureSection load='1n8o' size='340' side='right' caption='[[1n8o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='1n8o' size='340' side='right'caption='[[1n8o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1n8o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N8O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1n8o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N8O FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1azz|1azz]], [[1ecy|1ecy]], [[1fi8|1fi8]], [[1id5|1id5]], [[1ifg|1ifg]], [[1slu|1slu]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8o OCA], [https://pdbe.org/1n8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n8o RCSB], [https://www.ebi.ac.uk/pdbsum/1n8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n8o ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8o OCA], [http://pdbe.org/1n8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n8o RCSB], [http://www.ebi.ac.uk/pdbsum/1n8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1n8o ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ECOT_ECOLI ECOT_ECOLI]] General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity.[HAMAP-Rule:MF_00706]
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[https://www.uniprot.org/uniprot/CTRA_BOVIN CTRA_BOVIN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n8o ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n8o ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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==See Also==
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*[[Chymotrypsin 3D structures|Chymotrypsin 3D structures]]
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*[[Ecotin|Ecotin]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Chymotrypsin]]
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[[Category: Escherichia coli K-12]]
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Cambillau, C]]
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[[Category: Cambillau C]]
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[[Category: Lauwereys, M]]
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[[Category: Lauwereys M]]
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[[Category: Spinelli, S]]
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[[Category: Spinelli S]]
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[[Category: Hydrolase]]
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Crystal structure of a complex between bovine chymotrypsin and ecotin

PDB ID 1n8o

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