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1nnp

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(New page: 200px<br /><applet load="1nnp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nnp, resolution 1.90&Aring;" /> '''X-ray structure of t...)
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[[Image:1nnp.gif|left|200px]]<br /><applet load="1nnp" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1nnp, resolution 1.90&Aring;" />
 
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'''X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.'''<br />
 
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==Overview==
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==X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.==
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Two X-ray structures of the GluR2 ligand-binding core in complex with, (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid, ((S)-ATPA) have been determined with and without Zn(2+) ions. (S)-ATPA, induces a domain closure of ca. 21 degrees compared to the apo form. The, tert-butyl moiety of (S)-ATPA is buried in a partially hydrophobic pocket, and forces the ligand into the glutamate-like binding mode. The structures, provide new insight into the molecular basis of agonist selectivity, between AMPA and kainate receptors.
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<StructureSection load='1nnp' size='340' side='right'caption='[[1nnp]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nnp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NNP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CE2:3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE'>CE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nnp OCA], [https://pdbe.org/1nnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nnp RCSB], [https://www.ebi.ac.uk/pdbsum/1nnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nnp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/1nnp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nnp ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1NNP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with SO4 and CE2 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NNP OCA].
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
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== References ==
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==Reference==
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<references/>
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Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity., Lunn ML, Hogner A, Stensbol TB, Gouaux E, Egebjerg J, Kastrup JS, J Med Chem. 2003 Feb 27;46(5):872-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12593667 12593667]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Egebjerg J]]
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[[Category: Egebjerg, J.]]
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[[Category: Gouaux E]]
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[[Category: Gouaux, E.]]
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[[Category: Hogner A]]
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[[Category: Hogner, A.]]
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[[Category: Kastrup JS]]
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[[Category: Kastrup, J.S.]]
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[[Category: Lunn ML]]
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[[Category: Lunn, M.L.]]
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[[Category: Stensbol TB]]
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[[Category: Stensbol, T.B.]]
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[[Category: CE2]]
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[[Category: SO4]]
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[[Category: agonist complex.]]
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[[Category: ionotropic glutamate receptor glur2]]
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[[Category: ligand-binding core]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:24:49 2007''
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Current revision

X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.

PDB ID 1nnp

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