This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1oqv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1oqv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oqv, resolution 1.3&Aring;" /> '''Structure of TcpA, th...)
Current revision (06:09, 3 April 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1oqv.jpg|left|200px]]<br /><applet load="1oqv" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1oqv, resolution 1.3&Aring;" />
 
-
'''Structure of TcpA, the Type IV pilin subunit from the toxin co-regulated pilus of Vibrio cholerae classical biotype'''<br />
 
-
==Overview==
+
==Structure of TcpA, the Type IV pilin subunit from the toxin co-regulated pilus of Vibrio cholerae classical biotype==
-
Pilin assembly into type IV pili is required for virulence by bacterial, pathogens that cause diseases such as cholera, pneumonia, gonorrhea, and, meningitis. Crystal structures of soluble, N-terminally truncated pilin, from Vibrio cholera toxin-coregulated pilus (TCP) and full-length PAK, pilin from Pseudomonas aeruginosa reveal a novel TCP fold, yet a shared, architecture for the type IV pilins. In each pilin subunit a conserved, extended, N-terminal alpha helix wrapped by beta strands anchors the, structurally variable globular head. Inside the assembled pilus, characterized by cryo-electron microscopy and crystallography, the, extended hydrophobic alpha helices make multisubunit contacts to provide, mechanical strength and flexibility. Outside, distinct interactions of, adaptable heads contribute surface variation for specificity of pilus, function in antigenicity, motility, adhesion, and colony formation.
+
<StructureSection load='1oqv' size='340' side='right'caption='[[1oqv]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1oqv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OQV FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqv OCA], [https://pdbe.org/1oqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oqv RCSB], [https://www.ebi.ac.uk/pdbsum/1oqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oqv ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TCPA_VIBCL TCPA_VIBCL] Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oq/1oqv_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oqv ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1OQV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OQV OCA].
+
*[[Pilin 3D structures|Pilin 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin., Craig L, Taylor RK, Pique ME, Adair BD, Arvai AS, Singh M, Lloyd SJ, Shin DS, Getzoff ED, Yeager M, Forest KT, Tainer JA, Mol Cell. 2003 May;11(5):1139-50. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12769840 12769840]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Vibrio cholerae]]
[[Category: Vibrio cholerae]]
-
[[Category: Craig, L.]]
+
[[Category: Craig L]]
-
[[Category: Tainer, J.A.]]
+
[[Category: Tainer JA]]
-
[[Category: GOL]]
+
-
[[Category: adhesin]]
+
-
[[Category: fiber forming protein]]
+
-
[[Category: fimbriae]]
+
-
[[Category: pilin]]
+
-
[[Category: pilus filament]]
+
-
[[Category: tcpa]]
+
-
[[Category: type iv pilin]]
+
-
[[Category: vibrio cholerae]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 23:06:55 2007''
+

Current revision

Structure of TcpA, the Type IV pilin subunit from the toxin co-regulated pilus of Vibrio cholerae classical biotype

PDB ID 1oqv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1oqv"
Personal tools