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1rh4

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(New page: 200px<br /> <applet load="1rh4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rh4, resolution 1.9&Aring;" /> '''RH4 DESIGNED RIGHT-H...)
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[[Image:1rh4.gif|left|200px]]<br />
 
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<applet load="1rh4" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1rh4, resolution 1.9&Aring;" />
 
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'''RH4 DESIGNED RIGHT-HANDED COILED COIL TETRAMER'''<br />
 
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==Overview==
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==RH4 DESIGNED RIGHT-HANDED COILED COIL TETRAMER==
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Recent advances in computational techniques have allowed the design of, precise side-chain packing in proteins with predetermined, naturally, occurring backbone structures. Because these methods do not model protein, main-chain flexibility, they lack the breadth to explore novel backbone, conformations. Here the de novo design of a family of alpha-helical bundle, proteins with a right-handed superhelical twist is described. In the, design, the overall protein fold was specified by hydrophobic-polar, residue patterning, whereas the bundle oligomerization state, detailed, main-chain conformation, and interior side-chain rotamers were engineered, by computational enumerations of packing in alternate backbone structures., Main-chain flexibility was incorporated through an algebraic, parameterization of the backbone. The designed peptides form alpha-helical, dimers, trimers, and tetramers in accord with the design goals. The, crystal structure of the tetramer matches the designed structure in atomic, detail.
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<StructureSection load='1rh4' size='340' side='right'caption='[[1rh4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1rh4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. The October 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designer Proteins'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_10 10.2210/rcsb_pdb/mom_2005_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RH4 FirstGlance]. <br>
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1RH4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct] with ACE, NH2 and IPA as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1RH4 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RH4 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=IIL:ISO-ISOLEUCINE'>IIL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rh4 OCA], [https://pdbe.org/1rh4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rh4 RCSB], [https://www.ebi.ac.uk/pdbsum/1rh4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rh4 ProSAT]</span></td></tr>
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High-resolution protein design with backbone freedom., Harbury PB, Plecs JJ, Tidor B, Alber T, Kim PS, Science. 1998 Nov 20;282(5393):1462-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9822371 9822371]
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</table>
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__TOC__
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</StructureSection>
[[Category: Designer Proteins]]
[[Category: Designer Proteins]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: RCSB PDB Molecule of the Month]]
[[Category: Synthetic construct]]
[[Category: Synthetic construct]]
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[[Category: Alber, T.]]
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[[Category: Alber T]]
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[[Category: Harbury, P.B.]]
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[[Category: Harbury PB]]
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[[Category: Kim, P.S.]]
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[[Category: Kim PS]]
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[[Category: Plecs, J.J.]]
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[[Category: Plecs JJ]]
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[[Category: Tidor, B.]]
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[[Category: Tidor B]]
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[[Category: ACE]]
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[[Category: IPA]]
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[[Category: NH2]]
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[[Category: coiled coil]]
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[[Category: de novo design]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:05:29 2007''
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Current revision

RH4 DESIGNED RIGHT-HANDED COILED COIL TETRAMER

PDB ID 1rh4

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