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1snb
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1snb.png|left|200px]] | ||
| - | < | + | ==STRUCTURE OF SCORPION NEUROTOXIN BMK M8== |
| - | + | <StructureSection load='1snb' size='340' side='right'caption='[[1snb]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1snb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SNB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1snb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1snb OCA], [https://pdbe.org/1snb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1snb RCSB], [https://www.ebi.ac.uk/pdbsum/1snb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1snb ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SCX8_MESMA SCX8_MESMA] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This acidic toxin has a weak toxicity and is active against mammals. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sn/1snb_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1snb ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]] | |
| - | + | __TOC__ | |
| - | < | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
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[[Category: Mesobuthus martensii]] | [[Category: Mesobuthus martensii]] | ||
| - | + | [[Category: Li HM]] | |
| - | [[Category: Li | + | [[Category: Wang DC]] |
| - | [[Category: Wang | + | [[Category: Zeng ZH]] |
| - | [[Category: Zeng | + | |
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Current revision
STRUCTURE OF SCORPION NEUROTOXIN BMK M8
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