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1tl9

From Proteopedia

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{{Seed}}
 
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[[Image:1tl9.png|left|200px]]
 
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==High resolution crystal structure of calpain I protease core in complex with leupeptin==
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The line below this paragraph, containing "STRUCTURE_1tl9", creates the "Structure Box" on the page.
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<StructureSection load='1tl9' size='340' side='right'caption='[[1tl9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tl9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Streptomyces_roseus Streptomyces roseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TL9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AR7:AMINO{[(4S)-4-AMINO-5,5-DIHYDROXYPENTYL]AMINO}METHANIMINIUM'>AR7</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1tl9| PDB=1tl9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tl9 OCA], [https://pdbe.org/1tl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tl9 RCSB], [https://www.ebi.ac.uk/pdbsum/1tl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tl9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAN1_RAT CAN1_RAT] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tl/1tl9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tl9 ConSurf].
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<div style="clear:both"></div>
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===High resolution crystal structure of calpain I protease core in complex with leupeptin===
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==See Also==
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*[[Calpain 3D structures|Calpain 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15491615}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15491615 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15491615}}
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==About this Structure==
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1TL9 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TL9 OCA].
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==Reference==
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<ref group="xtra">PMID:15491615</ref><ref group="xtra">PMID:11893336</ref><ref group="xtra">PMID:12665854</ref><references group="xtra"/>
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[[Category: Calpain-1]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Campbell, R L.]]
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[[Category: Streptomyces roseus]]
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[[Category: Cuerrier, D.]]
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[[Category: Campbell RL]]
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[[Category: Davies, P L.]]
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[[Category: Cuerrier D]]
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[[Category: Moldoveanu, T.]]
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[[Category: Davies PL]]
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[[Category: Covalently-linked inhibitor at the active site cysteine forms a hemithioacetal]]
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[[Category: Moldoveanu T]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:31:25 2009''
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Current revision

High resolution crystal structure of calpain I protease core in complex with leupeptin

PDB ID 1tl9

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