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1wq8
From Proteopedia
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| - | [[Image:1wq8.png|left|200px]] | ||
| - | + | ==Crystal structure of Vammin, a VEGF-F from a snake venom== | |
| - | + | <StructureSection load='1wq8' size='340' side='right'caption='[[1wq8]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1wq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vipera_aspis_aspis Vipera aspis aspis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WQ8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wq8 OCA], [https://pdbe.org/1wq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1wq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wq8 ProSAT]</span></td></tr> |
| - | [[1wq8]] is a 1 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TXVE_VIPAA TXVE_VIPAA] Snake venom VEGFs may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension. The hypotension is mediated by nitric oxide (NO), which is produced by VEGF-activated endothelium NO synthase (PubMed:14600159). Also induces angiogenesis in vitro, probably through VEGF receptor (KDR/VEGFR-2) signaling (PubMed:14600159). May also induce capillary permeability through VEGF receptor (KDR/VEGFR-2) signaling.<ref>PMID:14600159</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/1wq8_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wq8 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[VEGF 3D Structures|VEGF 3D Structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Vipera aspis aspis]] | [[Category: Vipera aspis aspis]] | ||
| - | [[Category: Mizuno | + | [[Category: Mizuno H]] |
| - | [[Category: Morita | + | [[Category: Morita T]] |
| - | [[Category: Suto | + | [[Category: Suto K]] |
| - | [[Category: Yamazaki | + | [[Category: Yamazaki Y]] |
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Current revision
Crystal structure of Vammin, a VEGF-F from a snake venom
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