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1x2h

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{{Seed}}
 
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[[Image:1x2h.png|left|200px]]
 
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<!--
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==Crystal Structure of Lipate-Protein Ligase A from Escherichia coli complexed with lipoic acid==
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The line below this paragraph, containing "STRUCTURE_1x2h", creates the "Structure Box" on the page.
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<StructureSection load='1x2h' size='340' side='right'caption='[[1x2h]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1x2h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X2H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LPA:LIPOIC+ACID'>LPA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1x2h| PDB=1x2h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x2h OCA], [https://pdbe.org/1x2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x2h RCSB], [https://www.ebi.ac.uk/pdbsum/1x2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x2h ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of Lipate-Protein Ligase A from Escherichia coli complexed with lipoic acid===
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== Function ==
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[https://www.uniprot.org/uniprot/LPLA_ECOLI LPLA_ECOLI] Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Is also able to catalyze very poorly the transfer of lipoyl and octanoyl moiety from their acyl carrier protein.<ref>PMID:7639702</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16043486}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16043486 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/1x2h_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16043486}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1X2H is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X2H OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x2h ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:16043486</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Fujiwara, K.]]
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[[Category: Large Structures]]
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[[Category: Motokawa, Y.]]
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[[Category: Fujiwara K]]
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[[Category: Nakagawa, A.]]
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[[Category: Motokawa Y]]
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[[Category: Okamura-Ikeda, K.]]
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[[Category: Nakagawa A]]
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[[Category: Taniguchi, H.]]
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[[Category: Okamura-Ikeda K]]
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[[Category: Toma, S.]]
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[[Category: Taniguchi H]]
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[[Category: Lipoate-protein ligase]]
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[[Category: Toma S]]
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[[Category: Lipoic acid]]
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[[Category: Post-translational modification]]
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[[Category: Protein acylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:53:57 2009''
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Current revision

Crystal Structure of Lipate-Protein Ligase A from Escherichia coli complexed with lipoic acid

PDB ID 1x2h

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