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1xek

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[[Image:1xek.gif|left|200px]]<br />
 
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<applet load="1xek" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1xek, resolution 2.3&Aring;" />
 
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'''THE CRYSTAL STRUCTURES OF LYSOZYME AT VERY LOW LEVELS OF HYDRATION'''<br />
 
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==Overview==
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==THE CRYSTAL STRUCTURES OF LYSOZYME AT VERY LOW LEVELS OF HYDRATION==
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Earlier studies involving water-mediated transformations in lysozyme and, ribonuclease A have shown that the overall movements in the protein, molecule consequent to the reduction in the amount of surrounding water, are similar to those that occur during enzyme action, thus highlighting, the relationship among hydration, plasticity, and action of these enzymes., Monoclinic lysozyme retains its crystallinity even when the level of, hydration is reduced further below that necessary for activity (about 0.2, gram of water per gram of protein). In order to gain insights into the, role of water in the stability and the plasticity of the protein molecule, and the geometrical basis for the loss of activity that accompanies, dehydration, the crystal structures of monoclinic lysozyme with solvent, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9714162 (full description)]]
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<StructureSection load='1xek' size='340' side='right'caption='[[1xek]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xek]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XEK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xek OCA], [https://pdbe.org/1xek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xek RCSB], [https://www.ebi.ac.uk/pdbsum/1xek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xek ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/1xek_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xek ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1XEK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]]. Active as [[http://en.wikipedia.org/wiki/Hydrolase Hydrolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]]. Structure known Active Site: CAT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XEK OCA]].
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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==Reference==
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<references/>
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Role of water in plasticity, stability, and action of proteins: the crystal structures of lysozyme at very low levels of hydration., Nagendra HG, Sukumar N, Vijayan M, Proteins. 1998 Aug 1;32(2):229-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9714162 9714162]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Nagendra, H.G.]]
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[[Category: Gallus gallus]]
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[[Category: Sukumar, N.]]
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[[Category: Large Structures]]
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[[Category: Vijayan, M.]]
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[[Category: Nagendra HG]]
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[[Category: enzyme monoclinic 5% r.h. form]]
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[[Category: Sukumar N]]
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[[Category: hydrolase]]
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[[Category: Vijayan M]]
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[[Category: o-glycosyl]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:42:57 2007''
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Current revision

THE CRYSTAL STRUCTURES OF LYSOZYME AT VERY LOW LEVELS OF HYDRATION

PDB ID 1xek

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