This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1zei

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:21, 3 April 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1zei.png|left|200px]]
 
-
<!--
+
==CROSS-LINKED B28 ASP INSULIN==
-
The line below this paragraph, containing "STRUCTURE_1zei", creates the "Structure Box" on the page.
+
<StructureSection load='1zei' size='340' side='right'caption='[[1zei]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1zei]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZEI FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CRS:M-CRESOL'>CRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_1zei| PDB=1zei | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zei OCA], [https://pdbe.org/1zei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zei RCSB], [https://www.ebi.ac.uk/pdbsum/1zei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zei ProSAT]</span></td></tr>
-
 
+
</table>
-
===CROSS-LINKED B28 ASP INSULIN===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/INS_PIG INS_PIG] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_9708987}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 9708987 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ze/1zei_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_9708987}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1ZEI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZEI OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zei ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
__TOC__
-
Interactions of phenol and m-cresol in the insulin hexamer, and their effect on the association properties of B28 pro --&gt; Asp insulin analogues., Whittingham JL, Edwards DJ, Antson AA, Clarkson JM, Dodson GG, Biochemistry. 1998 Aug 18;37(33):11516-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9708987 9708987]
+
</StructureSection>
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
-
[[Category: Antson, A A.]]
+
[[Category: Antson AA]]
-
[[Category: Clarkson, J M.]]
+
[[Category: Clarkson JM]]
-
[[Category: Dodson, G G.]]
+
[[Category: Dodson GG]]
-
[[Category: Edwards, E J.]]
+
[[Category: Edwards EJ]]
-
[[Category: Whittingham, J L.]]
+
[[Category: Whittingham JL]]
-
[[Category: Chemical activity]]
+
-
[[Category: Cross-link]]
+
-
[[Category: Diabetes]]
+
-
[[Category: Glucose metabolism]]
+
-
[[Category: Hormone]]
+
-
[[Category: Insulin mutant]]
+
-
[[Category: Metabolic role]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:35:38 2008''
+

Current revision

CROSS-LINKED B28 ASP INSULIN

PDB ID 1zei

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zei"
Personal tools