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2bdi

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{{Seed}}
 
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[[Image:2bdi.png|left|200px]]
 
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==Human Kallikrein 4 complex with cobalt and p-aminobenzamidine==
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The line below this paragraph, containing "STRUCTURE_2bdi", creates the "Structure Box" on the page.
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<StructureSection load='2bdi' size='340' side='right'caption='[[2bdi]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bdi]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BDI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=PBZ:P-AMINO+BENZAMIDINE'>PBZ</scene></td></tr>
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{{STRUCTURE_2bdi| PDB=2bdi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdi OCA], [https://pdbe.org/2bdi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bdi RCSB], [https://www.ebi.ac.uk/pdbsum/2bdi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bdi ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[https://omim.org/entry/204700 204700]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN] Involved in enamel formation.<ref>PMID:15235027</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/2bdi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bdi ConSurf].
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<div style="clear:both"></div>
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===Human Kallikrein 4 complex with cobalt and p-aminobenzamidine===
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==See Also==
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*[[Kallikrein 3D structures|Kallikrein 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_16950394}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16950394 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_16950394}}
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==About this Structure==
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2BDI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDI OCA].
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==Reference==
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Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site., Debela M, Magdolen V, Grimminger V, Sommerhoff C, Messerschmidt A, Huber R, Friedrich R, Bode W, Goettig P, J Mol Biol. 2006 Oct 6;362(5):1094-107. Epub 2006 Aug 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16950394 16950394]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Goettig, P.]]
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[[Category: Bode W]]
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[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: Debela M]]
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[[Category: 70-80 loop]]
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[[Category: Goettig P]]
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[[Category: S1 subsite]]
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[[Category: Serine proteinase]]
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[[Category: Spine]]
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[[Category: Structural genomic]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:09:00 2008''
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Current revision

Human Kallikrein 4 complex with cobalt and p-aminobenzamidine

PDB ID 2bdi

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