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2fdp

From Proteopedia

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[[Image:2fdp.png|left|200px]]
 
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{{STRUCTURE_2fdp| PDB=2fdp | SCENE= }}
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==Crystal structure of beta-secretase complexed with an amino-ethylene inhibitor==
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<StructureSection load='2fdp' size='340' side='right'caption='[[2fdp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal structure of beta-secretase complexed with an amino-ethylene inhibitor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2fdp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FDP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16451048}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FRP:N1-((2S,3S,5R)-3-AMINO-6-(4-FLUOROPHENYLAMINO)-5-METHYL-6-OXO-1-PHENYLHEXAN-2-YL)-N3,N3-DIPROPYLISOPHTHALAMIDE'>FRP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fdp OCA], [https://pdbe.org/2fdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fdp RCSB], [https://www.ebi.ac.uk/pdbsum/2fdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fdp ProSAT]</span></td></tr>
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[[2fdp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FDP OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fd/2fdp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fdp ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Beta secretase|Beta secretase]]
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016451048</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Large Structures]]
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[[Category: Ballinger, M D.]]
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[[Category: Ballinger MD]]
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[[Category: Fucini, R V.]]
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[[Category: Fucini RV]]
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[[Category: Gordon, E M.]]
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[[Category: Gordon EM]]
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[[Category: Jacobs, J W.]]
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[[Category: Jacobs JW]]
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[[Category: Lam, M.]]
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[[Category: Lam M]]
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[[Category: Lu, W.]]
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[[Category: Lu W]]
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[[Category: Lu, Y.]]
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[[Category: Lu Y]]
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[[Category: McDowell, R S.]]
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[[Category: McDowell RS]]
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[[Category: Randal, M.]]
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[[Category: Randal M]]
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[[Category: Shi, X P.]]
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[[Category: Shi XP]]
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[[Category: Sun, J.]]
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[[Category: Sun J]]
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[[Category: Thomas, A E.]]
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[[Category: Thomas AE]]
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[[Category: Wilkinson, J M.]]
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[[Category: Wilkinson JM]]
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[[Category: Yang, W.]]
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[[Category: Yang W]]
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[[Category: Zhong, M.]]
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[[Category: Zhong M]]
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[[Category: Aspartyl protease]]
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[[Category: Bace]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of beta-secretase complexed with an amino-ethylene inhibitor

PDB ID 2fdp

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