2h0v

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(New page: 200px<br /><applet load="2h0v" size="450" color="white" frame="true" align="right" spinBox="true" caption="2h0v, resolution 2.600&Aring;" /> '''Crystal structure o...)
Current revision (06:27, 3 April 2024) (edit) (undo)
 
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[[Image:2h0v.gif|left|200px]]<br /><applet load="2h0v" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2h0v, resolution 2.600&Aring;" />
 
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'''Crystal structure of (2636545) from Bacillus subtilis at 2.60 A resolution'''<br />
 
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==About this Structure==
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==Crystal structure of a putative quercetin 2,3-dioxygenase (yxag, bsu39980) from bacillus subtilis at 2.60 A resolution==
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2H0V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with FE, EDO, TLA and TRS as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Quercetin_2,3-dioxygenase Quercetin 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.24 1.13.11.24] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2H0V OCA].
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<StructureSection load='2h0v' size='340' side='right'caption='[[2h0v]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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[[Category: Bacillus subtilis]]
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== Structural highlights ==
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[[Category: Quercetin 2,3-dioxygenase]]
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<table><tr><td colspan='2'>[[2h0v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H0V FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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[[Category: JCSG, Joint.Center.for.Structural.Genomics.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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[[Category: EDO]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h0v OCA], [https://pdbe.org/2h0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h0v RCSB], [https://www.ebi.ac.uk/pdbsum/2h0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h0v ProSAT], [https://www.topsan.org/Proteins/JCSG/2h0v TOPSAN]</span></td></tr>
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[[Category: FE]]
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</table>
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[[Category: TLA]]
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== Function ==
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[[Category: TRS]]
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[https://www.uniprot.org/uniprot/QDOI_BACSU QDOI_BACSU] Performs the first step in the degradation of the flavonoid quercetin by a dioxygenase reaction. The enzyme catalyzes the cleavage of the O-heteroaromatic ring of the flavonol quercetin yielding the depside 2-protocatechuoyl-phloroglucinol carboxylic acid and carbon monoxide. This involves the remarkable dioxygenolytic cleavage of two carbon-carbon bonds.<ref>PMID:14741339</ref>
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[[Category: 2636545]]
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== Evolutionary Conservation ==
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[[Category: jcsg]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: joint center for structural genomics]]
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Check<jmol>
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[[Category: protein structure initiative]]
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<jmolCheckbox>
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[[Category: psi-2]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/2h0v_consurf.spt"</scriptWhenChecked>
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[[Category: structural genomics]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h0v ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 11:29:35 2007''
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bacillus subtilis]]
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[[Category: Large Structures]]

Current revision

Crystal structure of a putative quercetin 2,3-dioxygenase (yxag, bsu39980) from bacillus subtilis at 2.60 A resolution

PDB ID 2h0v

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