This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2hcj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:27, 3 April 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2hcj.png|left|200px]]
 
-
<!--
+
==Trypsin-modified Elongation Factor Tu in complex with tetracycline==
-
The line below this paragraph, containing "STRUCTURE_2hcj", creates the "Structure Box" on the page.
+
<StructureSection load='2hcj' size='340' side='right'caption='[[2hcj]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2hcj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HCJ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GLV:GLYOXYLIC+ACID'>GLV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAC:TETRACYCLINE'>TAC</scene></td></tr>
-
{{STRUCTURE_2hcj| PDB=2hcj | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hcj OCA], [https://pdbe.org/2hcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hcj RCSB], [https://www.ebi.ac.uk/pdbsum/2hcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hcj ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/EFTU1_ECOLI EFTU1_ECOLI] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.[HAMAP-Rule:MF_00118] May play an important regulatory role in cell growth and in the bacterial response to nutrient deprivation.[HAMAP-Rule:MF_00118]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/2hcj_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hcj ConSurf].
 +
<div style="clear:both"></div>
-
==="Trypsin-modified Elongation Factor Tu in complex with tetracycline"===
+
==See Also==
-
 
+
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_17057344}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 17057344 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_17057344}}
+
-
 
+
-
==About this Structure==
+
-
2HCJ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCJ OCA].
+
-
 
+
-
==Reference==
+
-
Molecular complementarity between tetracycline and the GTPase active site of elongation factor Tu., Heffron SE, Mui S, Aorora A, Abel K, Bergmann E, Jurnak F, Acta Crystallogr D Biol Crystallogr. 2006 Nov;62(Pt 11):1392-400. Epub, 2006 Oct 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17057344 17057344]
+
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
-
[[Category: Abel, K.]]
+
[[Category: Abel K]]
-
[[Category: Aorora, A.]]
+
[[Category: Aorora A]]
-
[[Category: Bergmann, E.]]
+
[[Category: Bergmann E]]
-
[[Category: Heffron, S E.]]
+
[[Category: Heffron SE]]
-
[[Category: Jurnak, F.]]
+
[[Category: Jurnak F]]
-
[[Category: Mui, S.]]
+
[[Category: Mui S]]
-
[[Category: Complex with tetracycline]]
+
-
[[Category: Gtpase center]]
+
-
[[Category: Trypsin-modified ef-tu]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:55:59 2008''
+

Current revision

Trypsin-modified Elongation Factor Tu in complex with tetracycline

PDB ID 2hcj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hcj"
Personal tools