This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2nv7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2nv7" [edit=sysop:move=sysop])
Current revision (06:28, 3 April 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2nv7.png|left|200px]]
 
-
{{STRUCTURE_2nv7| PDB=2nv7 | SCENE= }}
+
==Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555==
-
 
+
<StructureSection load='2nv7' size='340' side='right'caption='[[2nv7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
===Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2nv7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NV7 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_17188490}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=555:4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE+OXIME'>555</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nv7 OCA], [https://pdbe.org/2nv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nv7 RCSB], [https://www.ebi.ac.uk/pdbsum/2nv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nv7 ProSAT]</span></td></tr>
-
[[2nv7]] is a 4 chain structure of [[Estrogen receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NV7 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nv/2nv7_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nv7 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Estrogen receptor|Estrogen receptor]]
+
*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:017188490</ref><references group="xtra"/>
+
-
[[Category: Histone acetyltransferase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Bowen, M S.]]
+
[[Category: Large Structures]]
-
[[Category: Cohn, S T.]]
+
[[Category: Bowen MS]]
-
[[Category: Harris, H A.]]
+
[[Category: Cohn ST]]
-
[[Category: Manas, E S.]]
+
[[Category: Harris HA]]
-
[[Category: Mewshaw, R E.]]
+
[[Category: Manas ES]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Mewshaw RE]]
-
[[Category: Xu, Z B.]]
+
[[Category: Xu ZB]]
-
[[Category: Agonist]]
+
-
[[Category: Er]]
+
-
[[Category: Er-beta]]
+
-
[[Category: Estrogen]]
+
-
[[Category: Estrogen receptor]]
+
-
[[Category: Estrogen receptor beta]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Nuclear receptor]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription factor]]
+

Current revision

Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555

PDB ID 2nv7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2nv7"
Personal tools