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2olx

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(New page: 200px<br /><applet load="2olx" size="350" color="white" frame="true" align="right" spinBox="true" caption="2olx, resolution 1.420&Aring;" /> '''Structure of NNQQ P...)
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[[Image:2olx.gif|left|200px]]<br /><applet load="2olx" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2olx, resolution 1.420&Aring;" />
 
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'''Structure of NNQQ Peptide from Yeast Prion SUP35'''<br />
 
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==Overview==
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==Structure of NNQQ Peptide from Yeast Prion SUP35==
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Amyloid fibrils formed from different proteins, each associated with a, particular disease, contain a common cross-beta spine. The atomic, architecture of a spine, from the fibril-forming segment GNNQQNY of the, yeast prion protein Sup35, was recently revealed by X-ray, microcrystallography. It is a pair of beta-sheets, with the facing side, chains of the two sheets interdigitated in a dry 'steric zipper'. Here we, report some 30 other segments from fibril-forming proteins that form, amyloid-like fibrils, microcrystals, or usually both. These include, segments from the Alzheimer's amyloid-beta and tau proteins, the PrP prion, protein, insulin, islet amyloid polypeptide (IAPP), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common, structural features are shared by amyloid diseases at the molecular level., Structures of 13 of these microcrystals all reveal steric zippers, but, with variations that expand the range of atomic architectures for, amyloid-like fibrils and offer an atomic-level hypothesis for the basis of, prion strains.
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<StructureSection load='2olx' size='340' side='right'caption='[[2olx]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2olx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OLX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2olx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2olx OCA], [https://pdbe.org/2olx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2olx RCSB], [https://www.ebi.ac.uk/pdbsum/2olx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2olx ProSAT]</span></td></tr>
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</table>
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==About this Structure==
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==See Also==
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2OLX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OLX OCA].
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*[[Prion 3D structures|Prion 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Atomic structures of amyloid cross-beta spines reveal varied steric zippers., Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D, Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17468747 17468747]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: Eisenberg D]]
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[[Category: Eisenberg, D.]]
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[[Category: Nelson R]]
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[[Category: Nelson, R.]]
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[[Category: Sawaya MR]]
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[[Category: Sawaya, M.R.]]
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[[Category: asparagine zipper]]
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[[Category: glutamine zipper]]
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[[Category: polar zipper]]
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[[Category: steric zipper]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:58:44 2008''
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Current revision

Structure of NNQQ Peptide from Yeast Prion SUP35

PDB ID 2olx

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