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2omp

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(New page: 200px<br /><applet load="2omp" size="350" color="white" frame="true" align="right" spinBox="true" caption="2omp, resolution 1.900&Aring;" /> '''LYQLEN peptide deri...)
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[[Image:2omp.gif|left|200px]]<br /><applet load="2omp" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2omp, resolution 1.900&Aring;" />
 
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'''LYQLEN peptide derived from human insulin chain A, residues 13-18'''<br />
 
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==Overview==
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==LYQLEN peptide derived from human insulin chain A, residues 13-18==
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Amyloid fibrils formed from different proteins, each associated with a, particular disease, contain a common cross-beta spine. The atomic, architecture of a spine, from the fibril-forming segment GNNQQNY of the, yeast prion protein Sup35, was recently revealed by X-ray, microcrystallography. It is a pair of beta-sheets, with the facing side, chains of the two sheets interdigitated in a dry 'steric zipper'. Here we, report some 30 other segments from fibril-forming proteins that form, amyloid-like fibrils, microcrystals, or usually both. These include, segments from the Alzheimer's amyloid-beta and tau proteins, the PrP prion, protein, insulin, islet amyloid polypeptide (IAPP), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common, structural features are shared by amyloid diseases at the molecular level., Structures of 13 of these microcrystals all reveal steric zippers, but, with variations that expand the range of atomic architectures for, amyloid-like fibrils and offer an atomic-level hypothesis for the basis of, prion strains.
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<StructureSection load='2omp' size='340' side='right'caption='[[2omp]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2omp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OMP FirstGlance]. <br>
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2OMP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OMP OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2omp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2omp OCA], [https://pdbe.org/2omp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2omp RCSB], [https://www.ebi.ac.uk/pdbsum/2omp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2omp ProSAT]</span></td></tr>
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==Reference==
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</table>
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Atomic structures of amyloid cross-beta spines reveal varied steric zippers., Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D, Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17468747 17468747]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Eisenberg, D.]]
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[[Category: Large Structures]]
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[[Category: Ivanova, M.I.]]
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[[Category: Eisenberg D]]
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[[Category: Sawaya, M.R.]]
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[[Category: Ivanova MI]]
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[[Category: antiparallel beta-sheet]]
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[[Category: Sawaya MR]]
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[[Category: steric zipper]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:58:48 2008''
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Current revision

LYQLEN peptide derived from human insulin chain A, residues 13-18

PDB ID 2omp

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