This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2p3b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:30, 3 April 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2p3b.png|left|200px]]
 
-
{{STRUCTURE_2p3b| PDB=2p3b | SCENE= }}
+
==Crystal Structure of the subtype B wild type HIV protease complexed with TL-3 inhibitor==
-
 
+
<StructureSection load='2p3b' size='340' side='right'caption='[[2p3b]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
===Crystal Structure of the subtype B wild type HIV protease complexed with TL-3 inhibitor===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2p3b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P3B FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_17467738}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TL:BENZYL+[(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-DIBENZYL-8,9-DIHYDROXY-1,16-DIMETHYL-4,13-BIS(1-METHYLETHYL)-2,5,12,15,18-PENTAOXO-20-PHENYL-19-OXA-3,6,11,14,17-PENTAAZAICOS-1-YL]CARBAMATE'>3TL</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p3b OCA], [https://pdbe.org/2p3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p3b RCSB], [https://www.ebi.ac.uk/pdbsum/2p3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p3b ProSAT]</span></td></tr>
-
[[2p3b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P3B OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q9Q2G8_9HIV1 Q9Q2G8_9HIV1]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p3/2p3b_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p3b ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Virus protease|Virus protease]]
+
*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:017467738</ref><references group="xtra"/>
+
-
[[Category: HIV-1 retropepsin]]
+
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
-
[[Category: Gustchina, A.]]
+
[[Category: Large Structures]]
-
[[Category: Krauchenco, S.]]
+
[[Category: Gustchina A]]
-
[[Category: Martins, N H.]]
+
[[Category: Krauchenco S]]
-
[[Category: Polikarpov, I.]]
+
[[Category: Martins NH]]
-
[[Category: Sanches, M.]]
+
[[Category: Polikarpov I]]
-
[[Category: Wlodawer, A.]]
+
[[Category: Sanches M]]
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
[[Category: Wlodawer A]]
-
[[Category: Tl-3 inhibitor]]
+
-
[[Category: Wild type subtype b hiv protease]]
+

Current revision

Crystal Structure of the subtype B wild type HIV protease complexed with TL-3 inhibitor

PDB ID 2p3b

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2p3b"
Personal tools