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2pos

From Proteopedia

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[[Image:2pos.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of sylvaticin, a new secreted protein from pythium sylvaticum==
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|PDB= 2pos |SIZE=350|CAPTION= <scene name='initialview01'>2pos</scene>, resolution 1.600&Aring;
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<StructureSection load='2pos' size='340' side='right'caption='[[2pos]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Ni+Binding+Site+For+Residue+B+100'>AC1</scene>, <scene name='pdbsite=AC2:Ni+Binding+Site+For+Residue+C+100'>AC2</scene>, <scene name='pdbsite=AC3:Ni+Binding+Site+For+Residue+D+100'>AC3</scene>, <scene name='pdbsite=AC4:Ni+Binding+Site+For+Residue+A+100'>AC4</scene>, <scene name='pdbsite=AC5:Cl+Binding+Site+For+Residue+A+3000'>AC5</scene>, <scene name='pdbsite=AC6:Trs+Binding+Site+For+Residue+B+2000'>AC6</scene>, <scene name='pdbsite=AC7:Trs+Binding+Site+For+Residue+C+2001'>AC7</scene>, <scene name='pdbsite=AC8:Trs+Binding+Site+For+Residue+D+2002'>AC8</scene> and <scene name='pdbsite=AC9:Trs+Binding+Site+For+Residue+A+2003'>AC9</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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<table><tr><td colspan='2'>[[2pos]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Globisporangium_sylvaticum Globisporangium sylvaticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2POS FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pos OCA], [https://pdbe.org/2pos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pos RCSB], [https://www.ebi.ac.uk/pdbsum/2pos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pos ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pos OCA], [http://www.ebi.ac.uk/pdbsum/2pos PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pos RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/D0VWX7_9STRA D0VWX7_9STRA]
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== Evolutionary Conservation ==
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'''Crystal Structure of sylvaticin, a new secreted protein from pythium sylvaticum'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/po/2pos_consurf.spt"</scriptWhenChecked>
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The structure of sylvaticin, a 10 kDa major pythin protein excreted by the parasitic oomycete Pythium sylvaticum, has been determined. Although closely related to alpha-elicitins in its biological response, toxicity and overall structure, sylvaticin presents a number of structural features that make it an unusual member of the elicitin class. Elicitins possess a large hydrophobic cavity and the mechanism of the systemic acquired resistance induced in planta is known to proceed through lipid transport and complexation within this cavity. Unlike other elicitins, sylvaticin contains tryptophan residues, one of which points inwards towards the central cavity, thus limiting access to sterols. In the case of sylvaticin, the sterol-transport mechanism is likely to be of less importance compared with other members of the elicitin family and still remains to be fully characterized.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2POS is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Pythium_sylvaticum Pythium sylvaticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POS OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pos ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structure of sylvaticin, a new alpha-elicitin-like protein from Pythium sylvaticum., Lascombe MB, Retailleau P, Ponchet M, Industri B, Blein JP, Prange T, Acta Crystallogr D Biol Crystallogr. 2007 Oct;63(Pt 10):1102-8. Epub 2007, Sep 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17881828 17881828]
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</StructureSection>
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[[Category: Protein complex]]
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[[Category: Globisporangium sylvaticum]]
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[[Category: Pythium sylvaticum]]
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[[Category: Large Structures]]
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[[Category: Lascombe, M B.]]
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[[Category: Lascombe MB]]
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[[Category: Prange, T.]]
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[[Category: Prange T]]
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[[Category: elicitin]]
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[[Category: sylvaticin]]
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[[Category: toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:39:00 2008''
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Current revision

Crystal Structure of sylvaticin, a new secreted protein from pythium sylvaticum

PDB ID 2pos

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