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2rd7

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{{STRUCTURE_2rd7| PDB=2rd7 | SCENE= }}
 
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===Human Complement Membrane Attack Proteins Share a Common Fold with Bacterial Cytolysins===
 
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==Disease==
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==Human Complement Membrane Attack Proteins Share a Common Fold with Bacterial Cytolysins==
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[[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[http://omim.org/entry/613790 613790]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
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<StructureSection load='2rd7' size='340' side='right'caption='[[2rd7]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[2rd7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RD7 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref><ref>PMID:17872444</ref> [[http://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN]] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rd7 OCA], [https://pdbe.org/2rd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rd7 RCSB], [https://www.ebi.ac.uk/pdbsum/2rd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rd7 ProSAT]</span></td></tr>
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[[2rd7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RD7 OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[https://omim.org/entry/613790 613790]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
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<references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref> <ref>PMID:17872444</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rd/2rd7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rd7 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chruszcz, M.]]
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[[Category: Large Structures]]
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[[Category: Lebioda, L.]]
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[[Category: Chruszcz M]]
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[[Category: Lovelace, L L.]]
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[[Category: Lebioda L]]
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[[Category: Minor, W.]]
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[[Category: Lovelace LL]]
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[[Category: Slade, D J.]]
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[[Category: Minor W]]
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[[Category: Sodetz, J M.]]
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[[Category: Slade DJ]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Sodetz JM]]
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[[Category: Complement alternate pathway]]
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[[Category: Complement pathway]]
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[[Category: Cytolysis]]
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[[Category: Egf-like domain]]
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[[Category: Glycoprotein]]
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[[Category: Immune response]]
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[[Category: Immune system]]
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[[Category: Innate immunity]]
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[[Category: Membrane attack complex]]
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[[Category: Membrane attack system]]
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[[Category: Secreted]]
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Current revision

Human Complement Membrane Attack Proteins Share a Common Fold with Bacterial Cytolysins

PDB ID 2rd7

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