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2rd7
From Proteopedia
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==Human Complement Membrane Attack Proteins Share a Common Fold with Bacterial Cytolysins== | ==Human Complement Membrane Attack Proteins Share a Common Fold with Bacterial Cytolysins== | ||
| - | <StructureSection load='2rd7' size='340' side='right' caption='[[2rd7]], [[Resolution|resolution]] 2.15Å' scene=''> | + | <StructureSection load='2rd7' size='340' side='right'caption='[[2rd7]], [[Resolution|resolution]] 2.15Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2rd7]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2rd7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RD7 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rd7 OCA], [https://pdbe.org/2rd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rd7 RCSB], [https://www.ebi.ac.uk/pdbsum/2rd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rd7 ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[https://omim.org/entry/613790 613790]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref> <ref>PMID:17872444</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rd/2rd7_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rd/2rd7_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rd7 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Chruszcz | + | [[Category: Large Structures]] |
| - | [[Category: Lebioda | + | [[Category: Chruszcz M]] |
| - | [[Category: Lovelace | + | [[Category: Lebioda L]] |
| - | [[Category: Minor | + | [[Category: Lovelace LL]] |
| - | [[Category: Slade | + | [[Category: Minor W]] |
| - | [[Category: Sodetz | + | [[Category: Slade DJ]] |
| - | + | [[Category: Sodetz JM]] | |
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Current revision
Human Complement Membrane Attack Proteins Share a Common Fold with Bacterial Cytolysins
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Categories: Homo sapiens | Large Structures | Chruszcz M | Lebioda L | Lovelace LL | Minor W | Slade DJ | Sodetz JM
