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3b4y

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{{STRUCTURE_3b4y| PDB=3b4y | SCENE= }}
 
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===FGD1 (Rv0407) from Mycobacterium tuberculosis===
 
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{{ABSTRACT_PUBMED_18434308}}
 
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==Function==
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==FGD1 (Rv0407) from Mycobacterium tuberculosis==
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[[http://www.uniprot.org/uniprot/P96253_MYCTU P96253_MYCTU]] Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Is essential for the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to an accessory protein (Rv3547), which in turn activates PA-824. Also probably has a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria.<ref>PMID:10879539</ref><ref>PMID:18434308</ref>
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<StructureSection load='3b4y' size='340' side='right'caption='[[3b4y]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3b4y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B4Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=F42:COENZYME+F420'>F42</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4y OCA], [https://pdbe.org/3b4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b4y RCSB], [https://www.ebi.ac.uk/pdbsum/3b4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b4y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FGD_MYCTU FGD_MYCTU] Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Is essential for the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to an accessory protein (Rv3547), which in turn activates PA-824. Also probably has a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria.<ref>PMID:10879539</ref> <ref>PMID:18434308</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/3b4y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b4y ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[3b4y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4Y OCA].
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*[[Glucose 6-phosphate dehydrogenase|Glucose 6-phosphate dehydrogenase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018434308</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Mycobacterium tuberculosis h37rv]]
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</StructureSection>
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[[Category: Baker, E N.]]
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[[Category: Large Structures]]
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[[Category: Bashiri, G.]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Moreland, N M.]]
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[[Category: Baker EN]]
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[[Category: Squire, C J.]]
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[[Category: Bashiri G]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Moreland NM]]
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[[Category: F420 binding]]
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[[Category: Squire CJ]]
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[[Category: Non-prolyl cis-peptide bulge]]
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[[Category: Oxidoreductase]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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[[Category: Tim-barrel]]
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Current revision

FGD1 (Rv0407) from Mycobacterium tuberculosis

PDB ID 3b4y

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