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3ca5

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{{Seed}}
 
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[[Image:3ca5.png|left|200px]]
 
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==Crystal structure of Sambucus nigra agglutinin II (SNA-II)-tetragonal crystal form- complexed to alpha1 methylgalactose==
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The line below this paragraph, containing "STRUCTURE_3ca5", creates the "Structure Box" on the page.
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<StructureSection load='3ca5' size='340' side='right'caption='[[3ca5]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ca5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sambucus_nigra Sambucus nigra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CA5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AMG:ALPHA-METHYL-D-GALACTOSIDE'>AMG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3ca5| PDB=3ca5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ca5 OCA], [https://pdbe.org/3ca5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ca5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ca5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ca5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NIGB_SAMNI NIGB_SAMNI] Non-toxic type 2 RIP which strongly inhibits mammalian protein synthesis but does not affect plant nor bacterial protein synthesis. The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain is a galactose-specific lectin that facilitates the binding of nigrin b to the cell membrane that precedes endocytosis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/3ca5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ca5 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Sambucus nigra agglutinin II (SNA-II)-tetragonal crystal form- complexed to alpha1 methylgalactose===
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==See Also==
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*[[Agglutinin 3D structures|Agglutinin 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18798567 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18798567}}
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==About this Structure==
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3CA5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sambucus_nigra Sambucus nigra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CA5 OCA].
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==Reference==
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Structural basis for sugar recognition, including the Tn carcinoma antigen, by the lectin SNA-II from Sambucus nigra., Maveyraud L, Niwa H, Guillet V, Svergun DI, Konarev PV, Palmer RA, Peumans WJ, Rouge P, Van Damme EJ, Reynolds CD, Mourey L, Proteins. 2008 Sep 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18798567 18798567]
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[[Category: Sambucus nigra]]
[[Category: Sambucus nigra]]
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[[Category: Single protein]]
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[[Category: Maveyraud L]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Mourey L]]
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[[Category: Beta-trefoil]]
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[[Category: Glycoprotein]]
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[[Category: Glycosylation]]
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[[Category: Lectin]]
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[[Category: Plant protein]]
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[[Category: Ricin-b domain]]
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[[Category: Signaling protein]]
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[[Category: Sugar binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 18 20:13:52 2009''
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Current revision

Crystal structure of Sambucus nigra agglutinin II (SNA-II)-tetragonal crystal form- complexed to alpha1 methylgalactose

PDB ID 3ca5

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