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3cfv
From Proteopedia
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| - | [[Image:3cfv.png|left|200px]] | ||
| - | + | ==Structural basis of the interaction of RbAp46/RbAp48 with histone H4== | |
| - | + | <StructureSection load='3cfv' size='340' side='right'caption='[[3cfv]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3cfv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CFV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARS:ARSENIC'>ARS</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cfv OCA], [https://pdbe.org/3cfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cfv RCSB], [https://www.ebi.ac.uk/pdbsum/3cfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cfv ProSAT]</span></td></tr> |
| - | [[3cfv]] is a 4 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RBBP7_HUMAN RBBP7_HUMAN] Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/3cfv_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cfv ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Retinoblastoma-binding protein|Retinoblastoma-binding protein]] | + | *[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Laue | + | [[Category: Large Structures]] |
| - | [[Category: Luisi | + | [[Category: Laue ED]] |
| - | [[Category: McLaughlin | + | [[Category: Luisi BF]] |
| - | [[Category: Murzina | + | [[Category: McLaughlin S]] |
| - | [[Category: Pei | + | [[Category: Murzina NV]] |
| - | [[Category: Verreault | + | [[Category: Pei X-Y]] |
| - | [[Category: Zhang | + | [[Category: Verreault A]] |
| - | + | [[Category: Zhang W]] | |
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Current revision
Structural basis of the interaction of RbAp46/RbAp48 with histone H4
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Categories: Homo sapiens | Large Structures | Laue ED | Luisi BF | McLaughlin S | Murzina NV | Pei X-Y | Verreault A | Zhang W
