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3cfv

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[[Image:3cfv.jpg|left|200px]]
 
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==Structural basis of the interaction of RbAp46/RbAp48 with histone H4==
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The line below this paragraph, containing "STRUCTURE_3cfv", creates the "Structure Box" on the page.
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<StructureSection load='3cfv' size='340' side='right'caption='[[3cfv]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cfv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CFV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARS:ARSENIC'>ARS</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3cfv| PDB=3cfv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cfv OCA], [https://pdbe.org/3cfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cfv RCSB], [https://www.ebi.ac.uk/pdbsum/3cfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cfv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RBBP7_HUMAN RBBP7_HUMAN] Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/3cfv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cfv ConSurf].
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<div style="clear:both"></div>
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'''Structural basis of the interaction of RbAp46/RbAp48 with histone H4'''
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==See Also==
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*[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3CFV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFV OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Ben-Shahar, T R.]]
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[[Category: Laue ED]]
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[[Category: McLaughlin, S.]]
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[[Category: Luisi BF]]
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[[Category: Verreault, A.]]
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[[Category: McLaughlin S]]
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[[Category: Zhang, W.]]
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[[Category: Murzina NV]]
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[[Category: Chaperone]]
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[[Category: Pei X-Y]]
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[[Category: Chromatin]]
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[[Category: Verreault A]]
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[[Category: Chromatin regulator]]
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[[Category: Zhang W]]
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[[Category: Chromosomal protein]]
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[[Category: Crystal structure]]
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[[Category: Dna replication]]
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[[Category: Dna-binding]]
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[[Category: Flexib]]
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[[Category: Histone]]
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[[Category: Histone/chaperone complex]]
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[[Category: Nucleosome core]]
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[[Category: Phosphoprotein]]
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[[Category: Rbap46/rbap48]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Wd repeat]]
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[[Category: Wd-40 repeat protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:49:04 2008''
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Current revision

Structural basis of the interaction of RbAp46/RbAp48 with histone H4

PDB ID 3cfv

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