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3ecm

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{{Seed}}
 
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[[Image:3ecm.jpg|left|200px]]
 
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<!--
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==Crystal structure of the unliganded PDE8A catalytic domain==
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The line below this paragraph, containing "STRUCTURE_3ecm", creates the "Structure Box" on the page.
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<StructureSection load='3ecm' size='340' side='right'caption='[[3ecm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ecm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ECM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3ecm| PDB=3ecm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ecm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ecm OCA], [https://pdbe.org/3ecm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ecm RCSB], [https://www.ebi.ac.uk/pdbsum/3ecm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ecm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE8A_HUMAN PDE8A_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.<ref>PMID:18983167</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/3ecm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ecm ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the unliganded PDE8A catalytic domain===
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18983167}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18983167 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18983167}}
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==About this Structure==
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3ECM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECM OCA].
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==Reference==
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Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity., Wang H, Yan Z, Yang S, Cai J, Robinson H, Ke H, Biochemistry. 2008 Nov 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18983167 18983167]
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cai, J.]]
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[[Category: Large Structures]]
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[[Category: Ke, H.]]
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[[Category: Cai J]]
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[[Category: Robinson, H.]]
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[[Category: Ke H]]
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[[Category: Wang, H.]]
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[[Category: Robinson H]]
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[[Category: Yan, Z.]]
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[[Category: Wang H]]
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[[Category: Yang, S.]]
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[[Category: Yan Z]]
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[[Category: Alternative splicing]]
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[[Category: Yang S]]
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[[Category: Camp]]
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[[Category: Hydrolase]]
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[[Category: Magnesium]]
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[[Category: Manganese]]
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[[Category: Metal-binding]]
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[[Category: Phosphodiesterase 8a pde8a inhibitor selectivity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 27 13:39:00 2008''
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Current revision

Crystal structure of the unliganded PDE8A catalytic domain

PDB ID 3ecm

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