This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3ecn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3ecn" [edit=sysop:move=sysop])
Current revision (06:36, 3 April 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3ecn.png|left|200px]]
 
-
{{STRUCTURE_3ecn| PDB=3ecn | SCENE= }}
+
==Crystal structure of PDE8A catalytic domain in complex with IBMX==
-
 
+
<StructureSection load='3ecn' size='340' side='right'caption='[[3ecn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
===Crystal structure of PDE8A catalytic domain in complex with IBMX===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3ecn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ECN FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_18983167}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ecn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ecn OCA], [https://pdbe.org/3ecn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ecn RCSB], [https://www.ebi.ac.uk/pdbsum/3ecn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ecn ProSAT]</span></td></tr>
-
[[3ecn]] is a 2 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECN OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PDE8A_HUMAN PDE8A_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.<ref>PMID:18983167</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/3ecn_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ecn ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Phosphodiesterase|Phosphodiesterase]]
+
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:018983167</ref><references group="xtra"/>
+
__TOC__
-
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Cai, J.]]
+
[[Category: Large Structures]]
-
[[Category: Ke, H.]]
+
[[Category: Cai J]]
-
[[Category: Robinson, H.]]
+
[[Category: Ke H]]
-
[[Category: Wang, H.]]
+
[[Category: Robinson H]]
-
[[Category: Yan, Z.]]
+
[[Category: Wang H]]
-
[[Category: Yang, S.]]
+
[[Category: Yan Z]]
-
[[Category: Camp]]
+
[[Category: Yang S]]
-
[[Category: Hydrolase]]
+
-
[[Category: Ibmx]]
+
-
[[Category: Magnesium]]
+
-
[[Category: Manganese]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Pde8a catalytic domain]]
+
-
[[Category: Refolding]]
+

Current revision

Crystal structure of PDE8A catalytic domain in complex with IBMX

PDB ID 3ecn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ecn"
Personal tools