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3eqv

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{{Seed}}
 
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[[Image:3eqv.png|left|200px]]
 
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<!--
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==Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing four mutations associated with penicillin resistance==
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The line below this paragraph, containing "STRUCTURE_3eqv", creates the "Structure Box" on the page.
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<StructureSection load='3eqv' size='340' side='right'caption='[[3eqv]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3eqv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EQV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3eqv| PDB=3eqv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eqv OCA], [https://pdbe.org/3eqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eqv RCSB], [https://www.ebi.ac.uk/pdbsum/3eqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eqv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PBP2_NEIGO PBP2_NEIGO] Synthesis of cross-linked peptidoglycan from the lipid intermediates.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eq/3eqv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eqv ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing four mutations associated with penicillin resistance===
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==See Also==
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*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_18986991}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18986991 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18986991}}
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==About this Structure==
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3EQV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EQV OCA].
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==Reference==
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Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and -resistant strains of N. gonorrhoeae reveal an unexpectedly subtle mechanism for antibiotic resistance., Powell AJ, Tomberg J, Deacon AM, Nicholas RA, Davies C, J Biol Chem. 2008 Nov 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18986991 18986991]
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[[Category: Neisseria gonorrhoeae]]
[[Category: Neisseria gonorrhoeae]]
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[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
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[[Category: Davies C]]
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[[Category: Davies, C.]]
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[[Category: Deacon AM]]
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[[Category: Deacon, A M.]]
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[[Category: Nicholas RA]]
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[[Category: Nicholas, R A.]]
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[[Category: Powell AJ]]
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[[Category: Powell, A J.]]
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[[Category: Biosynthetic protein]]
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[[Category: Cell division]]
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[[Category: Cell inner membrane]]
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[[Category: Cell membrane]]
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[[Category: Cell shape]]
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[[Category: Cell wall biogenesis/degradation]]
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[[Category: Class b transpeptidase]]
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[[Category: Penicillin resistance]]
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[[Category: Penicillin-binding protein]]
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[[Category: Peptidoglycan synthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 20 07:57:15 2008''
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Current revision

Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing four mutations associated with penicillin resistance

PDB ID 3eqv

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