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3ita

From Proteopedia

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[[Image:3ita.png|left|200px]]
 
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{{STRUCTURE_3ita| PDB=3ita | SCENE= }}
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==Crystal structure of Penicillin-Binding Protein 6 (PBP6) from E. coli in acyl-enzyme complex with ampicillin==
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<StructureSection load='3ita' size='340' side='right'caption='[[3ita]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Crystal structure of Penicillin-Binding Protein 6 (PBP6) from E. coli in acyl-enzyme complex with ampicillin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ita]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ITA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ITA FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19807181}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AIC:(2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC+ACID'>AIC</scene>, <scene name='pdbligand=AIX:(2R,4S)-2-[(1R)-1-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}-2-OXOETHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>AIX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ita FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ita OCA], [https://pdbe.org/3ita PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ita RCSB], [https://www.ebi.ac.uk/pdbsum/3ita PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ita ProSAT]</span></td></tr>
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[[3ita]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ITA OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DACC_ECOLI DACC_ECOLI] Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/it/3ita_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ita ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Carboxypeptidase|Carboxypeptidase]]
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*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
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*[[Penicillin-binding protein|Penicillin-binding protein]]
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019807181</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
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[[Category: Large Structures]]
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[[Category: Chen, Y.]]
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[[Category: Chen Y]]
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[[Category: Hesek, D.]]
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[[Category: Hesek D]]
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[[Category: Lee, M.]]
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[[Category: Lee M]]
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[[Category: Mobashery, S.]]
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[[Category: Mobashery S]]
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[[Category: Shi, Q.]]
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[[Category: Shi Q]]
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[[Category: Shoichet, B K.]]
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[[Category: Shoichet BK]]
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[[Category: Zhang, W.]]
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[[Category: Zhang W]]
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[[Category: Acyl-enzyme complex]]
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[[Category: Ampicillin]]
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[[Category: Bp6]]
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[[Category: Carboxypeptidase]]
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[[Category: Cell inner membrane]]
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[[Category: Cell membrane]]
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[[Category: Cell shape]]
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[[Category: Cell wall biogenesis/degradation]]
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[[Category: Dd-carboxypeptidase]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Peptidoglycan]]
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[[Category: Peptidoglycan synthesis]]
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[[Category: Ppenicillin-binding protein]]
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[[Category: Protease]]
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Current revision

Crystal structure of Penicillin-Binding Protein 6 (PBP6) from E. coli in acyl-enzyme complex with ampicillin

PDB ID 3ita

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