This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3ntp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:42, 3 April 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3ntp.jpg|left|200px]]
 
-
<!--
+
==Human Pin1 complexed with reduced amide inhibitor==
-
The line below this paragraph, containing "STRUCTURE_3ntp", creates the "Structure Box" on the page.
+
<StructureSection load='3ntp' size='340' side='right'caption='[[3ntp]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3ntp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NTP FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.762&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE8:3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL'>PE8</scene>, <scene name='pdbligand=RZD:(2R)-2-(ACETYLAMINO)-3-[(2S)-2-{[2-(1H-INDOL-3-YL)ETHYL]CARBAMOYL}PYRROLIDIN-1-YL]PROPYL+DIHYDROGEN+PHOSPHATE'>RZD</scene></td></tr>
-
{{STRUCTURE_3ntp| PDB=3ntp | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ntp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ntp OCA], [https://pdbe.org/3ntp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ntp RCSB], [https://www.ebi.ac.uk/pdbsum/3ntp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ntp ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
-
===Human Pin1 complexed with reduced amide inhibitor===
+
==See Also==
-
 
+
*[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21980916}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 21980916 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_21980916}}
+
-
 
+
-
==About this Structure==
+
-
[[3ntp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTP OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:021980916</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Peptidylprolyl isomerase]]
+
[[Category: Large Structures]]
-
[[Category: Zhang, Y.]]
+
[[Category: Zhang Y]]
-
[[Category: Isomerase-isomerase inhibitor complex]]
+
-
[[Category: Phosphorylation regulation]]
+
-
[[Category: Prolyl isomerase]]
+

Current revision

Human Pin1 complexed with reduced amide inhibitor

PDB ID 3ntp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ntp"
Personal tools