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3sor

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[[Image:3sor.jpg|left|200px]]
 
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==Factor XIa in complex with a clorophenyl-tetrazole inhibitor==
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The line below this paragraph, containing "STRUCTURE_3sor", creates the "Structure Box" on the page.
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<StructureSection load='3sor' size='340' side='right'caption='[[3sor]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sor]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SOR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=O58:{4-[(N-{3-[5-CHLORO-2-(1H-TETRAZOL-1-YL)PHENYL]PROPANOYL}-L-PHENYLALANYL)AMINO]PHENYL}ACETIC+ACID'>O58</scene></td></tr>
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{{STRUCTURE_3sor| PDB=3sor | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sor OCA], [https://pdbe.org/3sor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sor RCSB], [https://www.ebi.ac.uk/pdbsum/3sor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sor ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[https://omim.org/entry/612416 612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
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===Factor XIa in complex with a clorophenyl-tetrazole inhibitor===
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==See Also==
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*[[Factor XIa 3D structures|Factor XIa 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3sor]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOR OCA].
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__TOC__
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[[Category: Coagulation factor XIa]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kazemier, B.]]
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[[Category: Large Structures]]
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[[Category: Oubrie, A.]]
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[[Category: Kazemier B]]
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[[Category: Blood]]
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[[Category: Oubrie A]]
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[[Category: Coagulation factor]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Serine protease]]
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[[Category: Syntethic inhibitor]]
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Current revision

Factor XIa in complex with a clorophenyl-tetrazole inhibitor

PDB ID 3sor

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