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4jkv
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human smoothened 7TM receptor in complex with an antitumor agent== | |
| - | + | <StructureSection load='4jkv' size='340' side='right'caption='[[4jkv]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4jkv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JKV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1KS:4-FLUORO-N-METHYL-N-{1-[4-(1-METHYL-1H-PYRAZOL-5-YL)PHTHALAZIN-1-YL]PIPERIDIN-4-YL}-2-(TRIFLUOROMETHYL)BENZAMIDE'>1KS</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jkv OCA], [https://pdbe.org/4jkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jkv RCSB], [https://www.ebi.ac.uk/pdbsum/4jkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jkv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cherezov V]] | ||
| + | [[Category: Han GW]] | ||
| + | [[Category: Huang X]] | ||
| + | [[Category: Katritch V]] | ||
| + | [[Category: Liu W]] | ||
| + | [[Category: Roth BL]] | ||
| + | [[Category: Siu FY]] | ||
| + | [[Category: Stevens RC]] | ||
| + | [[Category: Wang C]] | ||
| + | [[Category: Wu H]] | ||
Current revision
Structure of the human smoothened 7TM receptor in complex with an antitumor agent
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Categories: Escherichia coli | Homo sapiens | Large Structures | Cherezov V | Han GW | Huang X | Katritch V | Liu W | Roth BL | Siu FY | Stevens RC | Wang C | Wu H
