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4w7t
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990== | |
| + | <StructureSection load='4w7t' size='340' side='right'caption='[[4w7t]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4w7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W7T FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3JC:(7S)-2-AMINO-4-METHYL-7-PHENYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE'>3JC</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w7t OCA], [https://pdbe.org/4w7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w7t RCSB], [https://www.ebi.ac.uk/pdbsum/4w7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w7t ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bellamacina CR]] | ||
| + | [[Category: Bussiere D]] | ||
| + | [[Category: Shafer CM]] | ||
Current revision
Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990
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