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5j1s

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'''Unreleased structure'''
 
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The entry 5j1s is ON HOLD
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==TorsinA-LULL1 complex, H. sapiens, bound to VHH-BS2==
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<StructureSection load='5j1s' size='340' side='right'caption='[[5j1s]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5j1s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J1S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.399&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j1s OCA], [https://pdbe.org/5j1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j1s RCSB], [https://www.ebi.ac.uk/pdbsum/5j1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j1s ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TOR1A_HUMAN TOR1A_HUMAN] Myoclonus-dystonia syndrome;Early-onset generalized limb-onset dystonia. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/TOR1A_HUMAN TOR1A_HUMAN] Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.<ref>PMID:15505207</ref> <ref>PMID:16361107</ref> <ref>PMID:17428918</ref> <ref>PMID:18167355</ref> <ref>PMID:18827015</ref> <ref>PMID:19339278</ref> <ref>PMID:20169475</ref> <ref>PMID:23569223</ref>
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Authors:
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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Description:
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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[[Category: Unreleased Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Vicugna pacos]]
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[[Category: Demircioglu FE]]
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[[Category: Schwartz TU]]

Current revision

TorsinA-LULL1 complex, H. sapiens, bound to VHH-BS2

PDB ID 5j1s

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