6x8s

Structural highlights

Function

CSP_PLABA Essential sporozoite protein (PubMed:6985745, PubMed:15630135, PubMed:16207248, PubMed:18005753, PubMed:21262960). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (PubMed:16207248, PubMed:21262960). In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes (PubMed:6985745, PubMed:15630135, PubMed:18005753, PubMed:21262960). Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (PubMed:18005753).^{[1] [2] [3] [4] [5]} In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.^{[6] [7]}

See Also

• Monoclonal Antibodies 3D structures

References

1. ↑ Coppi A, Pinzon-Ortiz C, Hutter C, Sinnis P. The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion. J Exp Med. 2005 Jan 3;201(1):27-33. PMID:15630135 doi:10.1084/jem.20040989
2. ↑ Wang Q, Fujioka H, Nussenzweig V. Mutational analysis of the GPI-anchor addition sequence from the circumsporozoite protein of Plasmodium. Cell Microbiol. 2005 Nov;7(11):1616-26. PMID:16207248 doi:10.1111/j.1462-5822.2005.00579.x
3. ↑ Coppi A, Tewari R, Bishop JR, Bennett BL, Lawrence R, Esko JD, Billker O, Sinnis P. Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells. Cell Host Microbe. 2007 Nov 15;2(5):316-27. PMID:18005753 doi:10.1016/j.chom.2007.10.002
4. ↑ Coppi A, Natarajan R, Pradel G, Bennett BL, James ER, Roggero MA, Corradin G, Persson C, Tewari R, Sinnis P. The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host. J Exp Med. 2011 Feb 14;208(2):341-56. PMID:21262960 doi:10.1084/jem.20101488
5. ↑ Yoshida N, Nussenzweig RS, Potocnjak P, Nussenzweig V, Aikawa M. Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite. Science. 1980 Jan 4;207(4426):71-3. PMID:6985745 doi:10.1126/science.6985745
6. ↑ Coppi A, Tewari R, Bishop JR, Bennett BL, Lawrence R, Esko JD, Billker O, Sinnis P. Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells. Cell Host Microbe. 2007 Nov 15;2(5):316-27. PMID:18005753 doi:10.1016/j.chom.2007.10.002
7. ↑ Coppi A, Natarajan R, Pradel G, Bennett BL, James ER, Roggero MA, Corradin G, Persson C, Tewari R, Sinnis P. The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host. J Exp Med. 2011 Feb 14;208(2):341-56. PMID:21262960 doi:10.1084/jem.20101488