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7kp8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==asymmetric mTNF-alpha hTNFR1 complex== | |
| + | <StructureSection load='7kp8' size='340' side='right'caption='[[7kp8]], [[Resolution|resolution]] 3.15Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7kp8]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KP8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A7G:1-{[2-(difluoromethoxy)phenyl]methyl}-2-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-benzimidazole'>A7G</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kp8 OCA], [https://pdbe.org/7kp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kp8 RCSB], [https://www.ebi.ac.uk/pdbsum/7kp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kp8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TNFA_MOUSE TNFA_MOUSE] Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Tumor necrosis factor 3D structures|Tumor necrosis factor 3D structures]] | |
| - | + | *[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]] | |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Arakaki TL]] | ||
| + | [[Category: Ceska T]] | ||
| + | [[Category: Edwards TE]] | ||
| + | [[Category: Foley A]] | ||
| + | [[Category: Fox III D]] | ||
Current revision
asymmetric mTNF-alpha hTNFR1 complex
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