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1hy9

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(New page: 200px<br /> <applet load="1hy9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hy9" /> '''COCAINE AND AMPHETAMINE REGULATED TRANSCRIP...)
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[[Image:1hy9.gif|left|200px]]<br />
 
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<applet load="1hy9" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hy9" />
 
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'''COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT'''<br />
 
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==Overview==
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==COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT==
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Cocaine and amphetamine regulated transcript (CART) peptide has been shown, to be an anorectic peptide that inhibits both normal and, starvation-induced feeding and completely blocks the feeding response, induced by neuropeptide Y and regulated by leptin in the hypothalamus. The, C-terminal part containing the three disulfide bridges CART(48-89) is the, biologically active part of the molecule affecting food intake. The, solution structure of the active part of CART has a fold equivalent to, other functionally distinct small proteins. CART consists mainly of turns, and loops spanned by a compact framework composed by a few small stretches, of antiparallel beta-sheet common to cystine knots.
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<StructureSection load='1hy9' size='340' side='right'caption='[[1hy9]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1hy9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HY9 FirstGlance]. <br>
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1HY9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HY9 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hy9 OCA], [https://pdbe.org/1hy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hy9 RCSB], [https://www.ebi.ac.uk/pdbsum/1hy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hy9 ProSAT]</span></td></tr>
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==Reference==
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</table>
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Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold., Ludvigsen S, Thim L, Blom AM, Wulff BS, Biochemistry. 2001 Aug 7;40(31):9082-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11478874 11478874]
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== Function ==
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[https://www.uniprot.org/uniprot/CART_HUMAN CART_HUMAN] Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.<ref>PMID:9590691</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/1hy9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hy9 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Blom, A.M.]]
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[[Category: Blom AM]]
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[[Category: Ludvigsen, S.]]
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[[Category: Ludvigsen S]]
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[[Category: Thim, L.]]
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[[Category: Thim L]]
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[[Category: Wulff, B.S.]]
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[[Category: Wulff BS]]
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[[Category: cysteine knot]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:24:09 2007''
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Current revision

COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT

PDB ID 1hy9

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