This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1i02

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:43, 3 April 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1i02.png|left|200px]]
 
-
<!--
+
==NMR STRUCTURE OF CTX A3 AT NEUTRAL PH (20 STRUCTURES)==
-
The line below this paragraph, containing "STRUCTURE_1i02", creates the "Structure Box" on the page.
+
<StructureSection load='1i02' size='340' side='right'caption='[[1i02]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1i02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I02 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i02 OCA], [https://pdbe.org/1i02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i02 RCSB], [https://www.ebi.ac.uk/pdbsum/1i02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i02 ProSAT]</span></td></tr>
-
{{STRUCTURE_1i02| PDB=1i02 | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/3SA3_NAJAT 3SA3_NAJAT] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells (PubMed:8182052). Interaction with sulfatides in the cell membrane induces pore formation and cell internalization. Cytotoxicity is due to pore formation, and to another mechanism independent of membrane-damaging activity. When internalized, it targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. It inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity (PubMed:16407244). It also binds with high affinity to heparin (PubMed:17685633).<ref>PMID:15922335</ref> <ref>PMID:16263708</ref> <ref>PMID:16407244</ref> <ref>PMID:17714752</ref> <ref>PMID:8182052</ref> <ref>PMID:8448165</ref> <ref>PMID:9245415</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/1i02_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i02 ConSurf].
 +
<div style="clear:both"></div>
-
===NMR STRUCTURE OF CTX A3 AT NEUTRAL PH (20 STRUCTURES)===
+
==See Also==
-
 
+
*[[Cardiotoxin 3D structures|Cardiotoxin 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_11669614}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 11669614 is the PubMed ID number.
+
</StructureSection>
-
-->
+
[[Category: Large Structures]]
-
{{ABSTRACT_PUBMED_11669614}}
+
-
 
+
-
==About this Structure==
+
-
1I02 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I02 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:11669614</ref><references group="xtra"/>
+
[[Category: Naja atra]]
[[Category: Naja atra]]
-
[[Category: Harold, J.]]
+
[[Category: Harold J]]
-
[[Category: Sue, S C.]]
+
[[Category: Sue S-C]]
-
[[Category: Wu, W g.]]
+
[[Category: Wu W-g]]
-
[[Category: Bound water]]
+
-
[[Category: Cardiotoxin]]
+
-
[[Category: Ctx]]
+
-
[[Category: Cytotoxin]]
+
-
[[Category: Gag binding protein]]
+
-
[[Category: Hemolysis]]
+
-
[[Category: Membrane binding protein]]
+
-
[[Category: Three-finger type]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:47:33 2009''
+

Current revision

NMR STRUCTURE OF CTX A3 AT NEUTRAL PH (20 STRUCTURES)

PDB ID 1i02

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i02"
Personal tools