1iad

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{{Seed}}
 
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[[Image:1iad.png|left|200px]]
 
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==REFINED 1.8 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF ASTACIN, A ZINC-ENDOPEPTIDASE FROM THE CRAYFISH ASTACUS ASTACUS L. STRUCTURE DETERMINATION, REFINEMENT, MOLECULAR STRUCTURE AND COMPARISON TO THERMOLYSIN==
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The line below this paragraph, containing "STRUCTURE_1iad", creates the "Structure Box" on the page.
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<StructureSection load='1iad' size='340' side='right'caption='[[1iad]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1iad]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Astacus_astacus Astacus astacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IAD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iad OCA], [https://pdbe.org/1iad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iad RCSB], [https://www.ebi.ac.uk/pdbsum/1iad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iad ProSAT]</span></td></tr>
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{{STRUCTURE_1iad| PDB=1iad | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ASTA_ASTAS ASTA_ASTAS] This protease prefers to cleave in front of small aliphatic residues (P1'). The presence of Lys or Arg in the P1 and P2 position yields high-turnover substrates. In the P3 position the enzyme prefers Pro > Val > Leu > Ala > Gly.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/1iad_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iad ConSurf].
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<div style="clear:both"></div>
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===REFINED 1.8 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF ASTACIN, A ZINC-ENDOPEPTIDASE FROM THE CRAYFISH ASTACUS ASTACUS L. STRUCTURE DETERMINATION, REFINEMENT, MOLECULAR STRUCTURE AND COMPARISON TO THERMOLYSIN===
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==See Also==
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*[[Proteinase 3D structures|Proteinase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8445658}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8445658 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8445658}}
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==About this Structure==
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1IAD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Astacus_astacus Astacus astacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IAD OCA].
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==Reference==
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Refined 1.8 A X-ray crystal structure of astacin, a zinc-endopeptidase from the crayfish Astacus astacus L. Structure determination, refinement, molecular structure and comparison with thermolysin., Gomis-Ruth FX, Stocker W, Huber R, Zwilling R, Bode W, J Mol Biol. 1993 Feb 20;229(4):945-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8445658 8445658]
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[[Category: Astacin]]
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[[Category: Astacus astacus]]
[[Category: Astacus astacus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bode, W.]]
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[[Category: Bode W]]
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[[Category: Gomis-Rueth, F X.]]
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[[Category: Gomis-Rueth F-X]]
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[[Category: Stoecker, W.]]
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[[Category: Stoecker W]]
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[[Category: Zinc endopeptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:39:54 2008''
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Current revision

REFINED 1.8 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF ASTACIN, A ZINC-ENDOPEPTIDASE FROM THE CRAYFISH ASTACUS ASTACUS L. STRUCTURE DETERMINATION, REFINEMENT, MOLECULAR STRUCTURE AND COMPARISON TO THERMOLYSIN

PDB ID 1iad

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